Pseudouridine synthase: Difference between revisions

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Wayne Decatur, Angel Herraez

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 <StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate   [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
 == Function ==
-'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>.  PUS are active in the ribosomal large subunit '''Ribosomal large subunit pseudouridine synthase''' and in the ribosomal small subunit ''Ribosomal small subunit pseudouridine synthase''.  Ribosomal large subunit pseudouridine synthase RluD is responsible for synthesis of pseudouridine from uracil in positions 1911, 1915 and 1917 in 23S ribosomal RNA<ref>PMID:15928344</ref>.  '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.
+'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>.  '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.  PUS are active in the ribosomal large subunit '''Ribosomal large subunit pseudouridine synthase''' and in the ribosomal small subunit '''Ribosomal small subunit pseudouridine synthase'''.<br />
+Ribosomal large subunit pseudouridine synthases:<br />
+*'''RluA''' is responsible for synthesis of pseudouridine from uracil in positions 746 in 23S ribosomal RNA and in the anticodon loop of tRNAPhe, tRNACys and tRNALeu<ref>PMID:17188032</ref>.<br />
+*'''RluB''' is responsible for synthesis of pseudouridine from uracil in position 2605 in 23S ribosomal RNA<ref>PMID:24214967</ref>.<br />
+*'''RluC''' is responsible for synthesis of pseudouridine from uracil in positions 955, 2504 and 2580 in 23S ribosomal RNA<ref>PMID:9660827</ref>.<br />
+*'''RluD''' is responsible for synthesis of pseudouridine from uracil in positions 1911, 1915 and 1917 in 23S ribosomal RNA<ref>PMID:15928344</ref>.<br />
+*'''RluE''' is responsible for synthesis of pseudouridine from uracil in position 2457 in 23S ribosomal RNA<ref>PMID:17320904</ref>.<br />
+*'''RluF''' is responsible for synthesis of pseudouridine from uracil in position 2604 in 23S ribosomal RNA<ref>PMID:16712869</ref>.<br />
 == Structural highlights ==