Pseudouridine synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Wayne Decatur, Angel Herraez

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 <StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate   [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
 == Function ==
-'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>.  PUS are active in the ribosomal large subunit [[Ribosomal large subunit pseudouridine synthase]] and ribosomal small subunit [[Ribosomal small subunit pseudouridine synthase]].  '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.
+'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>.  PUS are active in the ribosomal large subunit '''Ribosomal large subunit pseudouridine synthase''' and in the ribosomal small subunit ''Ribosomal small subunit pseudouridine synthase''.  Ribosomal large subunit pseudouridine synthase RluD is responsible for synthesis of pseudouridine from uracil in positions 1911, 1915 and 1917 in 23S ribosomal RNA<ref>PMID:15928344</ref>.  '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.
 == Structural highlights ==
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 **[[3hjy]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA<BR />
 **[[2apo]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 - ''Methanocaldococcus jannaschii''<BR />
+*Ribosomal large subunit pseudouridine synthase
+**[[2i82]] - EcRluA catalytic domain + RNA<br />
+**[[4lab]] - EcRluB catalytic domain <br />
+**[[4lgt]] - EcRluB catalytic domain + RNA<br />
+**[[1xpi]] - EcRluC catalytic domain<br />
+**[[5vbb]] - hRluC-like<br />
+**[[1prz]], [[1qyu]], [[1v9f]], [[1v9k]], [[2ist]] - EcRluD catalytic domain<br />
+**[[2oml]], [[2olw]] - EcRluE catalytic domain<br />
+**[[2gml]] - EcRluF catalytic domain<br />
+**[[3dh3]] - EcRluF catalytic domain + RNA<br />
+*Ribosomal small subunit pseudouridine synthase
+**[[1vio]] - RsuA - ''Haemophilus influenzae''<br />
+**[[1ksk]] - EcRsuA <br />
+**[[1ksl]] - EcRsuA + uracil<br />
+**[[1ksv]] - EcRsuA + UMP<br />
 }}
 == References ==
 <references/>
 [[Category:Topic Page]]