Myomesin: Difference between revisions
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== Function == | == Function == | ||
'''Myomesin''' or '''Skelemin''' is expressed in striated muscle cells. It contains type-III fibronectin (motif I) and C2-immunoglobulin (motif II) domains<ref>PMID:18521710</ref>. Myomesin is found in the M-bridges of sarcomeres which produce the muscle contraction and provide their elasticity. The giant protein [[Titin]] interconnects the major structure of sarcomeres - the M bands and Z discs. The C-terminal of titin binds to myomesin-1 and myomesin-2. Myomesin-1 and myomesin-2 have a unique N-terminal region followed by 12 motifs in the order of II-II-I-I-I-I-I-II-II-II-II-II<ref>PMID:15890201</ref>. | '''Myomesin''' or '''Skelemin''' is expressed in striated muscle cells. It contains type-III fibronectin (motif I) and C2-immunoglobulin (motif II) domains<ref>PMID:18521710</ref>. Myomesin is found in the M-bridges of sarcomeres which produce the muscle contraction and provide their elasticity. The giant protein [[Titin]] interconnects the major structure of sarcomeres - the M bands and Z discs. The C-terminal of titin binds to myomesin-1 and myomesin-2. Myomesin-1 and myomesin-2 have a unique N-terminal region followed by 12 motifs in the order of<br /> II-II-I-I-I-I-I-II-II-II-II-II<ref>PMID:15890201</ref>. | ||
== | == Relevance == | ||
The up-regulation of myimesin denotes an adaptive remodeling of the sarcomere cytoskeleton in dilated heart and mya serve as a marker for dilated cardiomyopathy<ref>PMID:21069531</ref>. | |||
== Structural highlights == | == Structural highlights == | ||