6fyu: Difference between revisions

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-'''Unreleased structure'''
-The entry 6fyu is ON HOLD  until Paper Publication
+==Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36==
+<StructureSection load='6fyu' size='340' side='right' caption='[[6fyu]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
-Authors: Laursen, N.S., Wilson, I.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6fyu]] is a 9 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FYU FirstGlance]. <br>
-Description: Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fyu OCA], [http://pdbe.org/6fyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fyu RCSB], [http://www.ebi.ac.uk/pdbsum/6fyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fyu ProSAT]</span></td></tr>
-[[Category: Wilson, I.A]]
+</table>
-[[Category: Laursen, N.S]]
+== Function ==
+[[http://www.uniprot.org/uniprot/A0A097PHH8_9INFA A0A097PHH8_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00046902] [[http://www.uniprot.org/uniprot/R4SCZ3_9INFA R4SCZ3_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[SAAS:SAAS01039674]  Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
+__TOC__
+</StructureSection>
+[[Category: Laursen, N S]]
+[[Category: Wilson, I A]]
+[[Category: Hemagglutinin]]
+[[Category: Influenza]]
+[[Category: Single domain antibody]]
+[[Category: Viral protein]]