2v2w: Difference between revisions

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|ACTIVITY=  
|ACTIVITY=  
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=[[1akj|1AKJ]], [[1ao7|1AO7]], [[1aqd|1AQD]], [[1b0g|1B0G]], [[1b0r|1B0R]], [[1bd2|1BD2]], [[1duy|1DUY]], [[1duz|1DUZ]], [[1eey|1EEY]], [[1eez|1EEZ]], [[1hhg|1HHG]], [[1hhh|1HHH]], [[1hhi|1HHI]], [[1hhj|1HHJ]], [[1hhk|1HHK]], [[1hla|1HLA]], [[1i1f|1I1F]], [[1i1y|1I1Y]], [[1i4f|1I4F]], [[1i7r|1I7R]], [[1i7t|1I7T]], [[1i7u|1I7U]], [[1im3|1IM3]], [[1jf1|1JF1]], [[1jht|1JHT]], [[1lp9|1LP9]], [[1oga|1OGA]], [[1p7q|1P7Q]], [[1qew|1QEW]], [[1qr1|1QR1]], [[1qrn|1QRN]], [[1qse|1QSE]], [[1qsf|1QSF]], [[1s8d|1S8D]], [[1s9w|1S9W]], [[1s9x|1S9X]], [[1s9y|1S9Y]], [[1t1w|1T1W]], [[1t1x|1T1X]], [[1t1y|1T1Y]], [[1t1z|1T1Z]], [[1t20|1T20]], [[1t21|1T21]], [[1t22|1T22]], [[1tvb|1TVB]], [[1tvh|1TVH]], [[1ur7|1UR7]], [[2av1|2AV1]], [[2av7|2AV7]], [[2bnq|2BNQ]], [[2bnr|2BNR]], [[2bsu|2BSU]], [[2bsv|2BSV]], [[2c7u|2C7U]], [[2clr|2CLR]], [[2gj6|2GJ6]], [[2jcc|2JCC]], [[2uwe|2UWE]], [[3hla|3HLA]], [[1a1m|1A1M]], [[1a1n|1A1N]], [[1a1o|1A1O]], [[1a6z|1A6Z]], [[1a9b|1A9B]], [[1a9e|1A9E]], [[1agb|1AGB]], [[1agc|1AGC]], [[1agd|1AGD]], [[1age|1AGE]], [[1agf|1AGF]], [[1c16|1C16]], [[1ce6|1CE6]], [[1cg9|1CG9]], [[1de4|1DE4]], [[1e27|1E27]], [[1e28|1E28]], [[1efx|1EFX]], [[1exu|1EXU]], [[1gzp|1GZP]], [[1gzq|1GZQ]], [[1hsa|1HSA]], [[1hsb|1HSB]], [[1im9|1IM9]], [[1jgd|1JGD]], [[1jge|1JGE]], [[1jnj|1JNJ]], [[1k5n|1K5N]], [[1kpr|1KPR]], [[1ktl|1KTL]], [[1lds|1LDS]], [[1m05|1M05]], [[1m6o|1M6O]], [[1mhe|1MHE]], [[1mi5|1MI5]], [[1n2r|1N2R]], [[1of2|1OF2]], [[1ogt|1OGT]], [[1onq|1ONQ]], [[1py4|1PY4]], [[1q94|1Q94]], [[1qlf|1QLF]], [[1qqd|1QQD]], [[1qvo|1QVO]], [[1r3h|1R3H]], [[1sys|1SYS]], [[1syv|1SYV]], [[1tmc|1TMC]], [[1uqs|1UQS]], [[1uxs|1UXS]], [[1uxw|1UXW]], [[1vgk|1VGK]], [[1w0v|1W0V]], [[1w0w|1W0W]], [[1w72|1W72]], [[1x7q|1X7Q]], [[1xh3|1XH3]], [[1xr8|1XR8]], [[1xr9|1XR9]], [[1xz0|1XZ0]], [[1ydp|1YDP]], [[1ypz|1YPZ]], [[1zs8|1ZS8]], [[1zsd|1ZSD]], [[1zt4|1ZT4]], [[2a83|2A83]], [[2ak4|2AK4]], [[2axf|2AXF]], [[2axg|2AXG]], [[2bck|2BCK]], [[2bsr|2BSR]], [[2bss|2BSS]], [[2bst|2BST]], [[2bvq|2BVQ]], [[2cii|2CII]], [[2cik|2CIK]], [[2d31|2D31]], [[2esv|2ESV]], [[2f74|2F74]], [[2f8o|2F8O]], [[2h26|2H26]], [[2hjk|2HJK]], [[2hjl|2HJL]], [[2hla|2HLA]], [[2v2x|2V2X]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2w OCA], [http://www.ebi.ac.uk/pdbsum/2v2w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v2w RCSB]</span>
}}
}}


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==Overview==
==Overview==
All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in infections such as the human immunodeficiency virus (HIV). To address this paradox, we analyzed the fine specificity of T cells recognizing a human histocompatibility leukocyte antigen (HLA)-A2-restricted, strongly immunodominant, HIV gag epitope (SLFNTVATL). The majority of 171 variant peptides tested bound HLA-A2, but only one third were recognized. Surprisingly, one recognized variant (SLYNTVATL) showed marked differences in structure when bound to HLA-A2. T cell receptor (TCR) recognition of variants of these two peptides implied that they adopted the same conformation in the TCR-peptide-major histocompatibility complex (MHC) complex. However, the on-rate kinetics of TCR binding were identical, implying that conformational changes at the TCR-peptide-MHC binding interface occur after an initial permissive antigen contact. These findings have implications for the rational design of vaccines targeting viruses with unstable genomes.
All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in infections such as the human immunodeficiency virus (HIV). To address this paradox, we analyzed the fine specificity of T cells recognizing a human histocompatibility leukocyte antigen (HLA)-A2-restricted, strongly immunodominant, HIV gag epitope (SLFNTVATL). The majority of 171 variant peptides tested bound HLA-A2, but only one third were recognized. Surprisingly, one recognized variant (SLYNTVATL) showed marked differences in structure when bound to HLA-A2. T cell receptor (TCR) recognition of variants of these two peptides implied that they adopted the same conformation in the TCR-peptide-major histocompatibility complex (MHC) complex. However, the on-rate kinetics of TCR binding were identical, implying that conformational changes at the TCR-peptide-MHC binding interface occur after an initial permissive antigen contact. These findings have implications for the rational design of vaccines targeting viruses with unstable genomes.
==Disease==
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Ankylosing spondylitis, susceptibility to, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]], Hypoproteinemia, hypercatabolic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109700 109700]], Stevens-Johnson syndrome, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142800 142800]]


==About this Structure==
==About this Structure==
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[[Category: ubl conjugation]]
[[Category: ubl conjugation]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:42:45 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:55 2008''

Revision as of 05:07, 31 March 2008

File:2v2w.jpg


PDB ID 2v2w

Drag the structure with the mouse to rotate
, resolution 1.60Å
Related: 1AKJ, 1AO7, 1AQD, 1B0G, 1B0R, 1BD2, 1DUY, 1DUZ, 1EEY, 1EEZ, 1HHG, 1HHH, 1HHI, 1HHJ, 1HHK, 1HLA, 1I1F, 1I1Y, 1I4F, 1I7R, 1I7T, 1I7U, 1IM3, 1JF1, 1JHT, 1LP9, 1OGA, 1P7Q, 1QEW, 1QR1, 1QRN, 1QSE, 1QSF, 1S8D, 1S9W, 1S9X, 1S9Y, 1T1W, 1T1X, 1T1Y, 1T1Z, 1T20, 1T21, 1T22, 1TVB, 1TVH, 1UR7, 2AV1, 2AV7, 2BNQ, 2BNR, 2BSU, 2BSV, 2C7U, 2CLR, 2GJ6, 2JCC, 2UWE, 3HLA, 1A1M, 1A1N, 1A1O, 1A6Z, 1A9B, 1A9E, 1AGB, 1AGC, 1AGD, 1AGE, 1AGF, 1C16, 1CE6, 1CG9, 1DE4, 1E27, 1E28, 1EFX, 1EXU, 1GZP, 1GZQ, 1HSA, 1HSB, 1IM9, 1JGD, 1JGE, 1JNJ, 1K5N, 1KPR, 1KTL, 1LDS, 1M05, 1M6O, 1MHE, 1MI5, 1N2R, 1OF2, 1OGT, 1ONQ, 1PY4, 1Q94, 1QLF, 1QQD, 1QVO, 1R3H, 1SYS, 1SYV, 1TMC, 1UQS, 1UXS, 1UXW, 1VGK, 1W0V, 1W0W, 1W72, 1X7Q, 1XH3, 1XR8, 1XR9, 1XZ0, 1YDP, 1YPZ, 1ZS8, 1ZSD, 1ZT4, 2A83, 2AK4, 2AXF, 2AXG, 2BCK, 2BSR, 2BSS, 2BST, 2BVQ, 2CII, 2CIK, 2D31, 2ESV, 2F74, 2F8O, 2H26, 2HJK, 2HJL, 2HLA, 2V2X


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT


OverviewOverview

All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in infections such as the human immunodeficiency virus (HIV). To address this paradox, we analyzed the fine specificity of T cells recognizing a human histocompatibility leukocyte antigen (HLA)-A2-restricted, strongly immunodominant, HIV gag epitope (SLFNTVATL). The majority of 171 variant peptides tested bound HLA-A2, but only one third were recognized. Surprisingly, one recognized variant (SLYNTVATL) showed marked differences in structure when bound to HLA-A2. T cell receptor (TCR) recognition of variants of these two peptides implied that they adopted the same conformation in the TCR-peptide-major histocompatibility complex (MHC) complex. However, the on-rate kinetics of TCR binding were identical, implying that conformational changes at the TCR-peptide-MHC binding interface occur after an initial permissive antigen contact. These findings have implications for the rational design of vaccines targeting viruses with unstable genomes.

About this StructureAbout this Structure

2V2W is a Protein complex structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 2BSU. Full crystallographic information is available from OCA.

ReferenceReference

T cell cross-reactivity and conformational changes during TCR engagement., Lee JK, Stewart-Jones G, Dong T, Harlos K, Di Gleria K, Dorrell L, Douek DC, van der Merwe PA, Jones EY, McMichael AJ, J Exp Med. 2004 Dec 6;200(11):1455-66. PMID:15583017

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