Negative elongation factor: Difference between revisions

Latest revision as of 13:05, 31 October 2018

Function

Negative elongation factor (NELF) induces RNA polymerase II promoter proximal pausing and limits provirus expression in HIV-infected T cells^[1].

Disease

NELF has been implicated in various diseases ranging from neurological disorders to cancer^[2].

Human NELF A (grey) complex with NELF C/D (green) and Cl- ion (green) (PDB code 5l3x)

Drag the structure with the mouse to rotate

3D structures of negative elongation factor3D structures of negative elongation factor

Updated on 31-October-2018

5l3x - hNELF A + NELF C/D - human
2bz2, 1x5p, 2jx2 - hNELF E RNA recognition motif - NMR
6gml - NELF A + NELF B + NELF C + NELF D + NELF E + RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA - pig - Cryo EM

ReferencesReferences

↑ Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ. Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013 Sep 6;288(36):25995-6003. doi: 10.1074/jbc.M113.496489. Epub, 2013 Jul 24. PMID:23884411 doi:http://dx.doi.org/10.1074/jbc.M113.496489
↑ Yung TM, Narita T, Komori T, Yamaguchi Y, Handa H. Cellular dynamics of the negative transcription elongation factor NELF. Exp Cell Res. 2009 Jun 10;315(10):1693-705. doi: 10.1016/j.yexcr.2009.02.013., Epub 2009 Feb 23. PMID:19245807 doi:http://dx.doi.org/10.1016/j.yexcr.2009.02.013

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

[1] Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ. Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013 Sep 6;288(36):25995-6003. doi: 10.1074/jbc.M113.496489. Epub, 2013 Jul 24. PMID:23884411 doi:http://dx.doi.org/10.1074/jbc.M113.496489

[2] Yung TM, Narita T, Komori T, Yamaguchi Y, Handa H. Cellular dynamics of the negative transcription elongation factor NELF. Exp Cell Res. 2009 Jun 10;315(10):1693-705. doi: 10.1016/j.yexcr.2009.02.013., Epub 2009 Feb 23. PMID:19245807 doi:http://dx.doi.org/10.1016/j.yexcr.2009.02.013

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@@ Line 1: / Line 1: @@
-<StructureSection load='5l3x' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='5l3x' size='340' side='right' caption='Human NELF A (grey) complex with NELF C/D (green) and Cl- ion (green) (PDB code [[5l3x]])' scene=''>
 == Function ==
@@ Line 8: / Line 8: @@
 NELF has been implicated in various diseases ranging from neurological disorders to cancer<ref>PMID:19245807</ref>.
-== Structural highlights ==
 </StructureSection>
@@ Line 20: / Line 17: @@
 [[5l3x]] - hNELF A + NELF C/D - human<br />
 [[2bz2]], [[1x5p]], [[2jx2]] - hNELF E RNA recognition motif - NMR<br />
-[[6gml]] - NELF A + NELF B + NELF C + NELF D + NELF E + RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA +  - pig - Cryo EM<br />
+[[6gml]] - NELF A + NELF B + NELF C + NELF D + NELF E + RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA - pig - Cryo EM<br />
 == References ==
 <references/>
 [[Category:Topic Page]]