2v01: Difference between revisions
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|PDB= 2v01 |SIZE=350|CAPTION= <scene name='initialview01'>2v01</scene>, resolution 2.15Å | |PDB= 2v01 |SIZE=350|CAPTION= <scene name='initialview01'>2v01</scene>, resolution 2.15Å | ||
|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene> | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1aji|1AJI]], [[1cdl|1CDL]], [[1cll|1CLL]], [[1ctr|1CTR]], [[1iwq|1IWQ]], [[1j7o|1J7O]], [[1j7p|1J7P]], [[1k90|1K90]], [[1k93|1K93]], [[1l7z|1L7Z]], [[1lvc|1LVC]], [[1nkf|1NKF]], [[1pk0|1PK0]], [[1s26|1S26]], [[1sk6|1SK6]], [[1sw8|1SW8]], [[1wrz|1WRZ]], [[1xfu|1XFU]], [[1xfv|1XFV]], [[1xfw|1XFW]], [[1xfx|1XFX]], [[1xfy|1XFY]], [[1xfz|1XFZ]], [[1y6w|1Y6W]], [[1yr5|1YR5]], [[1yrt|1YRT]], [[1yru|1YRU]], [[1zot|1ZOT]], [[2be6|2BE6]], [[2f3y|2F3Y]], [[2f3z|2F3Z]], [[2v02|2V02]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v01 OCA], [http://www.ebi.ac.uk/pdbsum/2v01 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v01 RCSB]</span> | |||
}} | }} | ||
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==Overview== | ==Overview== | ||
Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans. | Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Kursula, P.]] | [[Category: Kursula, P.]] | ||
[[Category: Majava, V.]] | [[Category: Majava, V.]] | ||
[[Category: acetylation]] | [[Category: acetylation]] | ||
[[Category: calcium]] | [[Category: calcium]] | ||
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[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:06:48 2008'' | ||
Revision as of 05:06, 31 March 2008
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| , resolution 2.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Related: | 1AJI, 1CDL, 1CLL, 1CTR, 1IWQ, 1J7O, 1J7P, 1K90, 1K93, 1L7Z, 1LVC, 1NKF, 1PK0, 1S26, 1SK6, 1SW8, 1WRZ, 1XFU, 1XFV, 1XFW, 1XFX, 1XFY, 1XFZ, 1Y6W, 1YR5, 1YRT, 1YRU, 1ZOT, 2BE6, 2F3Y, 2F3Z, 2V02
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RECOMBINANT VERTEBRATE CALMODULIN COMPLEXED WITH PB
OverviewOverview
Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.
About this StructureAbout this Structure
2V01 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
A structural insight into lead neurotoxicity and calmodulin activation by heavy metals., Kursula P, Majava V, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):653-6. Epub 2007 Jul 28. PMID:17671360
Page seeded by OCA on Mon Mar 31 05:06:48 2008