6epr: Difference between revisions

Revision as of 09:53, 31 October 2018

The ATAD2 bromodomain in complex with compound UZH-DS15The ATAD2 bromodomain in complex with compound UZH-DS15

Structural highlights

6epr is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Activity:	Adenosinetriphosphatase, with EC number 3.6.1.3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.^[1]

References

↑ Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12. PMID:17998543 doi:http://dx.doi.org/10.1073/pnas.0705814104

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12. PMID:17998543 doi:http://dx.doi.org/10.1073/pnas.0705814104

[1]

6epr: Difference between revisions

Revision as of 09:53, 31 October 2018

The ATAD2 bromodomain in complex with compound UZH-DS15The ATAD2 bromodomain in complex with compound UZH-DS15

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Revision as of 09:52, 31 October 2018 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits New page: ==The ATAD2 bromodomain in complex with compound UZH-DS15== <StructureSection load='6epr' size='340' side='right' caption='6epr, resolution 2.05Å' scene=''> == St...	Revision as of 09:53, 31 October 2018 view source OCA (talk \| contribs) Bots, Bureaucrats, Administrators 3,175,590 edits m Protected "6epr" [edit=sysop:move=sysop] Newer edit →
(No difference)

6epr: Difference between revisions

Revision as of 09:53, 31 October 2018

The ATAD2 bromodomain in complex with compound UZH-DS15The ATAD2 bromodomain in complex with compound UZH-DS15

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search