6emm: Difference between revisions

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'''Unreleased structure'''


The entry 6emm is ON HOLD
==17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with Salicylic acid==
 
<StructureSection load='6emm' size='340' side='right' caption='[[6emm]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
Authors: Bertoletti, N., Marchais-Oberwinkler, S., Heine, A., Klebe, G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6emm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EMM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EMM FirstGlance]. <br>
Description: 17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with Salicylic acid
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6emm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6emm OCA], [http://pdbe.org/6emm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6emm RCSB], [http://www.ebi.ac.uk/pdbsum/6emm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6emm ProSAT]</span></td></tr>
[[Category: Marchais-Oberwinkler, S]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bertoletti, N]]
[[Category: Heine, A]]
[[Category: Heine, A]]
[[Category: Bertoletti, N]]
[[Category: Klebe, G]]
[[Category: Klebe, G]]
[[Category: Marchais-Oberwinkler, S]]
[[Category: 17b-hsd14]]
[[Category: Fragment]]
[[Category: Oxidoreductase]]
[[Category: Soaking]]

Revision as of 09:52, 31 October 2018

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with Salicylic acid17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with Salicylic acid

Structural highlights

6emm is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DHB14_HUMAN] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).[1]

References

  1. ↑ Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Lee WH, Adamski J, Oppermann U. Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. Biochem J. 2007 Mar 15;402(3):419-27. PMID:17067289 doi:BJ20061319

6emm, resolution 2.47Å

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