5z4j: Difference between revisions

Revision as of 09:45, 31 October 2018

Structure of Tailor in complex with U4 RNAStructure of Tailor in complex with U4 RNA

Structural highlights

5z4j is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:	RNA uridylyltransferase, with EC number 2.7.7.52
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TUTT_DROME] Uridylyltransferase which mediates terminal uridylation of miRNAs, leading to their degradation. Has high specificity for splicing-derived miRNAs (mirtrons) and other miRNA substrates containing a 3'-G terminal nucleotide. Appears to be a major suppressor of mirtron biogenesis.^[1] ^[2]

References

↑ Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell. 2015 Jul 16;59(2):217-28. doi: 10.1016/j.molcel.2015.05.034. Epub 2015 , Jul 2. PMID:26145174 doi:http://dx.doi.org/10.1016/j.molcel.2015.05.034
↑ Reimao-Pinto MM, Ignatova V, Burkard TR, Hung JH, Manzenreither RA, Sowemimo I, Herzog VA, Reichholf B, Farina-Lopez S, Ameres SL. Uridylation of RNA Hairpins by Tailor Confines the Emergence of MicroRNAs in Drosophila. Mol Cell. 2015 Jul 16;59(2):203-16. doi: 10.1016/j.molcel.2015.05.033. Epub 2015 , Jul 2. PMID:26145176 doi:http://dx.doi.org/10.1016/j.molcel.2015.05.033

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell. 2015 Jul 16;59(2):217-28. doi: 10.1016/j.molcel.2015.05.034. Epub 2015 , Jul 2. PMID:26145174 doi:http://dx.doi.org/10.1016/j.molcel.2015.05.034

[2] Reimao-Pinto MM, Ignatova V, Burkard TR, Hung JH, Manzenreither RA, Sowemimo I, Herzog VA, Reichholf B, Farina-Lopez S, Ameres SL. Uridylation of RNA Hairpins by Tailor Confines the Emergence of MicroRNAs in Drosophila. Mol Cell. 2015 Jul 16;59(2):203-16. doi: 10.1016/j.molcel.2015.05.033. Epub 2015 , Jul 2. PMID:26145176 doi:http://dx.doi.org/10.1016/j.molcel.2015.05.033

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5z4j is ON HOLD  until Jan 11 2020
+==Structure of Tailor in complex with U4 RNA==
+<StructureSection load='5z4j' size='340' side='right' caption='[[5z4j]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
-Authors: Cheng, L., Li, F., Jiang, Y., Yu, H., Xie, C., Shi, Y., Gong, Q.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5z4j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z4J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z4J FirstGlance]. <br>
-Description: Structure of Tailor in complex with U4 RNA
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_uridylyltransferase RNA uridylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.52 2.7.7.52] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z4j OCA], [http://pdbe.org/5z4j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z4j RCSB], [http://www.ebi.ac.uk/pdbsum/5z4j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z4j ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TUTT_DROME TUTT_DROME]] Uridylyltransferase which mediates terminal uridylation of miRNAs, leading to their degradation. Has high specificity for splicing-derived miRNAs (mirtrons) and other miRNA substrates containing a 3'-G terminal nucleotide. Appears to be a major suppressor of mirtron biogenesis.<ref>PMID:26145174</ref> <ref>PMID:26145176</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: RNA uridylyltransferase]]
 [[Category: Cheng, L]]
-[[Category: Yu, H]]
 [[Category: Gong, Q]]
+[[Category: Jiang, Y]]
+[[Category: Li, F]]
 [[Category: Shi, Y]]
-[[Category: Jiang, Y]]
 [[Category: Xie, C]]
-[[Category: Li, F]]
+[[Category: Yu, H]]
+[[Category: Terminal uridylyltransferase]]
+[[Category: Transferase-rna complex]]

5z4j: Difference between revisions

Revision as of 09:45, 31 October 2018

Structure of Tailor in complex with U4 RNAStructure of Tailor in complex with U4 RNA

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

5z4j: Difference between revisions

Revision as of 09:45, 31 October 2018

Structure of Tailor in complex with U4 RNAStructure of Tailor in complex with U4 RNA

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search