6ew6: Difference between revisions

Revision as of 08:55, 24 October 2018

Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligandCrystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand

Structural highlights

6ew6 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	5n21, 5n20, 5n1z, 5n1x
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

Function

[BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.^[1] ^[2]

References

↑ Niu H, Ye BH, Dalla-Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 1998 Jul 1;12(13):1953-61. PMID:9649500
↑ Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243 doi:10.1016/j.molcel.2007.12.026

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OCA

[1] Niu H, Ye BH, Dalla-Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 1998 Jul 1;12(13):1953-61. PMID:9649500

[2] Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Prive GG. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell. 2008 Feb 15;29(3):384-91. PMID:18280243 doi:10.1016/j.molcel.2007.12.026

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ew6 is ON HOLD
+==Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand==
+<StructureSection load='6ew6' size='340' side='right' caption='[[6ew6]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
-Authors: Robb, G., Ferguson, A., Hargreaves, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ew6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EW6 FirstGlance]. <br>
-Description: Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C0H:~{N}2-(2-chlorophenyl)-1,3,5-triazine-2,4-diamine'>C0H</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5n21|5n21]], [[5n20|5n20]], [[5n1z|5n1z]], [[5n1x|5n1x]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ew6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ew6 OCA], [http://pdbe.org/6ew6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ew6 RCSB], [http://www.ebi.ac.uk/pdbsum/6ew6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ew6 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
+== Function ==
+[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ferguson, A]]
+[[Category: Hargreaves, D]]
 [[Category: Robb, G]]
-[[Category: Hargreaves, D]]
+[[Category: Kinase]]
-[[Category: Ferguson, A]]
+[[Category: Transferase]]

6ew6: Difference between revisions

Revision as of 08:55, 24 October 2018

Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligandCrystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand

Structural highlights

Disease

Function

References

Contents

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6ew6: Difference between revisions

Revision as of 08:55, 24 October 2018

Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligandCrystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand

Structural highlights

Disease

Function

References

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