Ribonucleotide reductase: Difference between revisions
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== Function == | == Function == | ||
'''Ribonucleotide reductase''' (RNR) or '''ribonucleotide-diphosphate reductase''' catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br /> | '''Ribonucleotide reductase''' (RNR) or '''ribonucleotide-diphosphate reductase''' catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br /> | ||
* '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.<br /> | * '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction<ref>PMID:21456967</ref>.<br /> | ||
* ''' Class Ib RNR''' contains 2 proteins: α (NrdE) and β (NrdF).<br /> | * ''' Class Ib RNR''' contains 2 proteins: α (NrdE) and β (NrdF)<ref>PMID:21250660</ref>.<br /> | ||
* ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br /> | * ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12<ref>PMID:11875520</ref>.<br /> | ||
* '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center.<br /> | * '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center<ref>PMID:17606358</ref>.<br /> | ||
For details on human RNR2 see [[P53R2]].<br /> | For details on human RNR2 see [[P53R2]].<br /> | ||
For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].<br /> | For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].<br /> | ||