6d1s: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1s OCA], [http://pdbe.org/6d1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1s RCSB], [http://www.ebi.ac.uk/pdbsum/6d1s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1s ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1s OCA], [http://pdbe.org/6d1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1s RCSB], [http://www.ebi.ac.uk/pdbsum/6d1s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and report the structure of IP6-activated arrestin-3 at 2.4-A resolution. IP6-activated arrestin-3 exhibits an inter-domain twist and a displaced C-tail, hallmarks of active arrestin. IP6 binds to the arrestin phosphate sensor, and is stabilized by trimerization. Analysis of the trimerization surface, which is also the receptor-binding surface, suggests a feature called the finger loop as a key region of the activation sensor. We show that finger loop helicity and flexibility may underlie coupling to hundreds of diverse receptors and also promote arrestin-3 activation by IP6. Importantly, we show that effector-binding sites on arrestins have distinct conformations in the basal and activated states, acting as switch regions. These switch regions may work with the inter-domain twist to initiate and direct arrestin-mediated signaling. | |||
Structural basis of arrestin-3 activation and signaling.,Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM Nat Commun. 2017 Nov 10;8(1):1427. doi: 10.1038/s41467-017-01218-8. PMID:29127291<ref>PMID:29127291</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 6d1s" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:31, 10 October 2018
Crystal structure of an apo chimeric human alpha1GABAA receptorCrystal structure of an apo chimeric human alpha1GABAA receptor
Structural highlights
Publication Abstract from PubMedA unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and report the structure of IP6-activated arrestin-3 at 2.4-A resolution. IP6-activated arrestin-3 exhibits an inter-domain twist and a displaced C-tail, hallmarks of active arrestin. IP6 binds to the arrestin phosphate sensor, and is stabilized by trimerization. Analysis of the trimerization surface, which is also the receptor-binding surface, suggests a feature called the finger loop as a key region of the activation sensor. We show that finger loop helicity and flexibility may underlie coupling to hundreds of diverse receptors and also promote arrestin-3 activation by IP6. Importantly, we show that effector-binding sites on arrestins have distinct conformations in the basal and activated states, acting as switch regions. These switch regions may work with the inter-domain twist to initiate and direct arrestin-mediated signaling. Structural basis of arrestin-3 activation and signaling.,Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM Nat Commun. 2017 Nov 10;8(1):1427. doi: 10.1038/s41467-017-01218-8. PMID:29127291[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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