2r1c: Difference between revisions
New page: left|200px {{Structure |PDB= 2r1c |SIZE=350|CAPTION= <scene name='initialview01'>2r1c</scene> |SITE= |LIGAND= |ACTIVITY= |GENE= TTHA0907 ([http://www.ncbi.nlm.nih.g... |
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= TTHA0907 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]) | |GENE= TTHA0907 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1jos|1JOS]], [[2dyj|2DYJ]], [[2r1g|2R1G]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r1c OCA], [http://www.ebi.ac.uk/pdbsum/2r1c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r1c RCSB]</span> | |||
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[[Category: rrna processing]] | [[Category: rrna processing]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:55:32 2008'' | ||
Revision as of 04:55, 31 March 2008
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| Gene: | TTHA0907 (Thermus thermophilus) | ||||||
| Related: | 1JOS, 2DYJ, 2R1G
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Coordinates of the thermus thermophilus ribosome binding factor A (RbfA) homology model as fitted into the CRYO-EM map of a 30S-RBFA complex
OverviewOverview
Ribosome binding factor A (RbfA) is a bacterial cold shock response protein, required for an efficient processing of the 5' end of the 16S ribosomal RNA (rRNA) during assembly of the small (30S) ribosomal subunit. Here we present a crystal structure of Thermus thermophilus (Tth) RbfA and a three-dimensional cryo-electron microscopic (EM) map of the Tth 30S*RbfA complex. RbfA binds to the 30S subunit in a position overlapping the binding sites of the A and P site tRNAs, and RbfA's functionally important C terminus extends toward the 5' end of the 16S rRNA. In the presence of RbfA, a portion of the 16S rRNA encompassing helix 44, which is known to be directly involved in mRNA decoding and tRNA binding, is displaced. These results shed light on the role played by RbfA during maturation of the 30S subunit, and also indicate how RbfA provides cells with a translational advantage under conditions of cold shock.
About this StructureAbout this Structure
2R1C is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
ReferenceReference
Structural aspects of RbfA action during small ribosomal subunit assembly., Datta PP, Wilson DN, Kawazoe M, Swami NK, Kaminishi T, Sharma MR, Booth TM, Takemoto C, Fucini P, Yokoyama S, Agrawal RK, Mol Cell. 2007 Nov 9;28(3):434-45. PMID:17996707
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