5qef: Difference between revisions

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'''Unreleased structure'''


The entry 5qef is ON HOLD
==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134a==
 
<StructureSection load='5qef' size='340' side='right' caption='[[5qef]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Keedy, D.A., Hill, Z.B., Biel, J.T., Kang, E., Rettenmaier, T.J., Brandao-Neto, J., von Delft, F., Wells, J.A., Fraser, J.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5qef]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QEF FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal structure of PTP1B in complex with compound_FMOPL000134a
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JJ7:1-{4-[(2-methoxyethyl)amino]piperidin-1-yl}ethan-1-one'>JJ7</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
[[Category: Biel, J.T]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qef OCA], [http://pdbe.org/5qef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qef RCSB], [http://www.ebi.ac.uk/pdbsum/5qef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qef ProSAT]</span></td></tr>
[[Category: Rettenmaier, T.J]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Biel, J T]]
[[Category: Brandao-Neto, J]]
[[Category: Brandao-Neto, J]]
[[Category: Keedy, D.A]]
[[Category: Delft, F von]]
[[Category: Wells, J.A]]
[[Category: Fraser, J S]]
[[Category: Hill, Z.B]]
[[Category: Hill, Z B]]
[[Category: Fraser, J.S]]
[[Category: Kang, E]]
[[Category: Kang, E]]
[[Category: Von Delft, F]]
[[Category: Keedy, D A]]
[[Category: Rettenmaier, T J]]
[[Category: Wells, J A]]
[[Category: Allostery]]
[[Category: Enzyme]]
[[Category: Hydrolase]]
[[Category: Multiconformer]]
[[Category: Pandda]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Ptp]]
[[Category: Ptp1b]]
[[Category: Sgc - diamond i04-1 fragment screening]]

Revision as of 10:51, 10 October 2018

PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134aPanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000134a

Structural highlights

5qef is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Protein-tyrosine-phosphatase, with EC number 3.1.3.48
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.[1] [2]

References

  1. ↑ Nievergall E, Janes PW, Stegmayer C, Vail ME, Haj FG, Teng SW, Neel BG, Bastiaens PI, Lackmann M. PTP1B regulates Eph receptor function and trafficking. J Cell Biol. 2010 Dec 13;191(6):1189-203. doi: 10.1083/jcb.201005035. Epub 2010, Dec 6. PMID:21135139 doi:10.1083/jcb.201005035
  2. ↑ Krishnan N, Fu C, Pappin DJ, Tonks NK. H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal. 2011 Dec 13;4(203):ra86. doi: 10.1126/scisignal.2002329. PMID:22169477 doi:10.1126/scisignal.2002329

5qef, resolution 1.60Å

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