UvrABC: Difference between revisions
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<StructureSection load='3pih' size=' | <StructureSection load='3pih' size='3 | ||
50' side='right' caption='UvrA complex with DNA, pyrophosphate and Zn+2 ion (grey) [[3pih]]' scene='' > | |||
== Function == | == Function == | ||
'''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | '''UvrABC''' endonuclease is an ''E. coli'' enzyme complex involved in DNA repair. UvrABC removes 12 nucleotides around a DNA mutation replacing them with the correct one<ref>PMID:11004168</ref>.<br /> | ||
* '''UvrA''' is the protein which locates the DNA damage.<br /> | * '''UvrA''' is the protein which locates the DNA damage<ref>PMID:21240268</ref>.<br /> | ||
* '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br /> | * '''UvrB''' is involved in distinguishing damaged from undamaged DNA<ref>PMID:10946234</ref>.<br /> | ||
* The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>. | * The C-terminal region of '''UvrC''' is involved in DNA binding and incisions at the 5'-side of a DNA damage during nucleotide excision repair<ref>PMID:9421501</ref>. | ||