5ype: Difference between revisions
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== | ==p62/SQSTM1 ZZ domain with Tyr-peptide== | ||
<StructureSection load='5ype' size='340' side='right' caption='[[5ype]], [[Resolution|resolution]] 2.85Å' scene=''> | <StructureSection load='5ype' size='340' side='right' caption='[[5ype]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ype]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YPE FirstGlance]. <br> | <table><tr><td colspan='2'>[[5ype]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YPE FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SQSTM1, ORCA, OSIL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ype FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ype OCA], [http://pdbe.org/5ype PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ype RCSB], [http://www.ebi.ac.uk/pdbsum/5ype PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ype ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ype FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ype OCA], [http://pdbe.org/5ype PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ype RCSB], [http://www.ebi.ac.uk/pdbsum/5ype PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ype ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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</div> | </div> | ||
<div class="pdbe-citations 5ype" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5ype" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Sequestosome|Sequestosome]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Kim, L]] | [[Category: Kim, L]] | ||
[[Category: Kwon, D H]] | [[Category: Kwon, D H]] | ||
Revision as of 11:35, 3 October 2018
p62/SQSTM1 ZZ domain with Tyr-peptidep62/SQSTM1 ZZ domain with Tyr-peptide
Structural highlights
Disease[GRP78_HUMAN] Note=Autoantigen in rheumatoid arthritis.[1] Function[GRP78_HUMAN] Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.[2] Publication Abstract from PubMedp62/SQSTM1 is the key autophagy adapter protein and the hub of multi-cellular signaling. It was recently reported that autophagy and N-end rule pathways are linked via p62. However, the exact recognition mode of degrading substrates and regulation of p62 in the autophagic pathway remain unknown. Here, we present the complex structures between the ZZ-domain of p62 and various type-1 and type-2 N-degrons. The binding mode employed in the interaction of the ZZ-domain with N-degrons differs from that employed by classic N-recognins. It was also determined that oligomerization via the PB1 domain can control functional affinity to the R-BiP substrate. Unexpectedly, we found that self-oligomerization and disassembly of p62 are pH-dependent. These findings broaden our understanding of the functional repertoire of the N-end rule pathway and provide an insight into the regulation of p62 during the autophagic pathway. Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter.,Kwon DH, Park OH, Kim L, Jung YO, Park Y, Jeong H, Hyun J, Kim YK, Song HK Nat Commun. 2018 Aug 17;9(1):3291. doi: 10.1038/s41467-018-05825-x. PMID:30120248[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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