6b61: Difference between revisions

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'''Unreleased structure'''


The entry 6b61 is ON HOLD  until Paper Publication
==IMPase (AF2372) with 25 mM Asp==
 
<StructureSection load='6b61' size='340' side='right' caption='[[6b61]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
Authors: Goldstein, R.I., Roberts, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6b61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B61 FirstGlance]. <br>
Description: IMPase (AF2372) with 25 mM Asp
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b61 OCA], [http://pdbe.org/6b61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b61 RCSB], [http://www.ebi.ac.uk/pdbsum/6b61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b61 ProSAT]</span></td></tr>
[[Category: Goldstein, R.I]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/BSUHB_ARCFU BSUHB_ARCFU]] Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.<ref>PMID:10747806</ref> <ref>PMID:11062561</ref> <ref>PMID:11940584</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Goldstein, R I]]
[[Category: Roberts, M]]
[[Category: Roberts, M]]
[[Category: Hydrolase]]
[[Category: Inositol monophosphatase]]
[[Category: Osmolyte binding protein]]

Revision as of 10:44, 3 October 2018

IMPase (AF2372) with 25 mM AspIMPase (AF2372) with 25 mM Asp

Structural highlights

6b61 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BSUHB_ARCFU] Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.[1] [2] [3]

References

  1. ↑ Chen L, Roberts MF. Overexpression, purification, and analysis of complementation behavior of E. coli SuhB protein: comparison with bacterial and archaeal inositol monophosphatases. Biochemistry. 2000 Apr 11;39(14):4145-53. PMID:10747806
  2. ↑ Stec B, Yang H, Johnson KA, Chen L, Roberts MF. MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase. Nat Struct Biol. 2000 Nov;7(11):1046-50. PMID:11062561 doi:10.1038/80968
  3. ↑ Stieglitz KA, Johnson KA, Yang H, Roberts MF, Seaton BA, Head JF, Stec B. Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J Biol Chem. 2002 Jun 21;277(25):22863-74. Epub 2002 Apr 8. PMID:11940584 doi:http://dx.doi.org/10.1074/jbc.M201042200

6b61, resolution 2.70Å

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