5vvp: Difference between revisions

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-'''Unreleased structure'''
-The entry 5vvp is ON HOLD  until Paper Publication
+==HLA-B*57:03 presenting LSSPVTKSW==
+<StructureSection load='5vvp' size='340' side='right' caption='[[5vvp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Pymm, P., Rossjohn, J., Vivian, J.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vvp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VVP FirstGlance]. <br>
-Description: HLA-B*57:03 presenting LSSPVTKSW
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vud|5vud]], [[5vue|5vue]], [[5vuf|5vuf]], [[5vwd|5vwd]], [[5vwf|5vwf]], [[5vwh|5vwh]], [[5vwj|5vwj]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vvp OCA], [http://pdbe.org/5vvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vvp RCSB], [http://www.ebi.ac.uk/pdbsum/5vvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vvp ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/I3ZN84_HUMAN I3ZN84_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00291881] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Pymm, P]]
 [[Category: Rossjohn, J]]
-[[Category: Vivian, J.P]]
+[[Category: Vivian, J P]]
+[[Category: Antigen presentation]]
+[[Category: Human leukocyte antigen]]
+[[Category: Immune system]]