Pseudouridine synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Wayne Decatur, Angel Herraez

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 <StructureSection load='1ze2' size='400' side='right' caption='tRNA pseudouridine synthase complex with RNA and pseudouridine monophosphate   [[1ze2]]' scene='46/465439/Cv/1' pspeed='8'>
 == Function ==
-'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>.  PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu).  '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.
+'''tRNA pseudouridine synthase''' (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine<ref>PMID:14566049</ref>.  PUS are active in the ribosomal large subunit [[Ribosomal large subunit pseudouridine synthase]] and ribosomal small subunit [[Ribosomal small subunit pseudouridine synthase]].  '''Probable tRNA pseudouridine synthase''' (PPUS) is a similar enzyme.
 == Structural highlights ==
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 **[[1zl3]] - EcTruB (mutant) + stem-loop RNA<BR />
 **[[2nqp]], [[2nr0]], [[2nre]] – EcTruA + Leu-tRNA<BR />
-**[[3hjw]], [[3lwo]], [[3lwp]], [[3lwq]], [[3lwr]], [[3lwv]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA  – ''Pyrococcus furiosus''<BR />
-**[[3mqk]] - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA<BR />
-**[[3hjy]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA<BR />
 **[[1ze2]] - TmPUS B + RNA<BR />
 **[[2ab4]] - TmPUS B (mutant) + RNA<BR />
 **[[1r3e]], [[1r3f]] - EcTruB + RNA<BR />
+*Probable tRNA pseudouridine synthase
+**[[3hjw]], [[3lwo]], [[3lwp]], [[3lwq]], [[3lwr]], [[3lwv]], [[3hax]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA  – ''Pyrococcus furiosus''<BR />
+**[[3hay]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA + small nuclear RNP protein<BR />
+**[[2hvy]] – PfPUS Cbf5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA + small nuclear RNP protein + small nuclear RNP Gar1-like protein<BR />
+**[[3mqk]] - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA<BR />
+**[[2rfk]] - PfPUS Cbf5 (mutant) + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA<BR />
+**[[2ey4]] - PfPUS Cbf5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein <BR />
+**[[3hjy]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 + RNA<BR />
+**[[2apo]] - PfPUS Cbf5 + ribosome biogenesis protein NOP10 - ''Methanocaldococcus jannaschii''<BR />
 }}
 == References ==
 <references/>
 [[Category:Topic Page]]