2qfa: Difference between revisions
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|PDB= 2qfa |SIZE=350|CAPTION= <scene name='initialview01'>2qfa</scene>, resolution 1.400Å | |PDB= 2qfa |SIZE=350|CAPTION= <scene name='initialview01'>2qfa</scene>, resolution 1.400Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= BIRC5, API4, IAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CDCA8, PESCRG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), INCENP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= BIRC5, API4, IAP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CDCA8, PESCRG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), INCENP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfa OCA], [http://www.ebi.ac.uk/pdbsum/2qfa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qfa RCSB]</span> | |||
}} | }} | ||
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[[Category: Lindner, D.]] | [[Category: Lindner, D.]] | ||
[[Category: Nigg, E A.]] | [[Category: Nigg, E A.]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: apoptosis]] | [[Category: apoptosis]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:48:39 2008'' | ||
Revision as of 04:48, 31 March 2008
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| , resolution 1.400Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | BIRC5, API4, IAP4 (Homo sapiens), CDCA8, PESCRG3 (Homo sapiens), INCENP (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a Survivin-Borealin-INCENP core complex
OverviewOverview
The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis. CPC functions are connected to its localization. The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. We determined the 1.4 A resolution crystal structure of the regulatory core of the CPC, revealing that Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. We used siRNA rescue experiments with structure-based mutants to explore the requirements for CPC localization. We show that the intertwined structural interactions of the core components lead to functional interdependence. Association of the core "passenger" proteins creates a single structural unit, whose composite molecular surface presents conserved residues essential for central spindle and midbody localization.
About this StructureAbout this Structure
2QFA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together., Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E, Cell. 2007 Oct 19;131(2):271-85. PMID:17956729
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Protein complex
- Conti, E.
- Ebert, J.
- Jeyaprakash, A A.
- Klein, U R.
- Lindner, D.
- Nigg, E A.
- Alternative splicing
- Apoptosis
- Cell cycle
- Cell cycle/cell cycle/cell cycle complex
- Cell division
- Centromere
- Chromosomal protein
- Coiled coil
- Cytoplasm
- Long helix
- Metal-binding
- Microtubule
- Mitosis
- Nucleus
- Phosphorylation
- Polymorphism
- Protease inhibitor
- Thiol protease inhibitor
- Three-helical-bundle
- Zinc