Siderocalin: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' > | ||
== Function == | == Function == | ||
'''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | '''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | ||
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*Siderocalin or lipocalin-2 | *Siderocalin or lipocalin-2 | ||
**[[5jr8]], [[3bx8]], [[5khp]], [[5kid]], [[5kic]] – hScn NGAL - human<br /> | **[[5jr8]], [[3bx8]], [[5khp]], [[5kid]], [[5kic]], [[5mhh]], [[6gqz]] – hScn NGAL - human<br /> | ||
**[[3s26]] – mScn NGAL - mouse<br /> | **[[3s26]] – mScn NGAL - mouse<br /> | ||
**[[2kt4]] – qScn Q83 – quail<br /> | **[[2kt4]] – qScn Q83 – quail<br /> | ||
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**[[3hwe]], [[3hwf]], [[3hwg]], [[3cmp]], [[3by0]], [[3cbc]] – hScn NGAL (mutant) + siderophore + Fe<br /> | **[[3hwe]], [[3hwf]], [[3hwg]], [[3cmp]], [[3by0]], [[3cbc]] – hScn NGAL (mutant) + siderophore + Fe<br /> | ||
**[[3fw4]], [[3fw5]] – hScn NGAL (mutant) + catechol + Fe<br /> | **[[3fw4]], [[3fw5]] – hScn NGAL (mutant) + catechol + Fe<br /> | ||
**[[4gh7]] – hScn NGAL + fibronectin<br /> | **[[4gh7]], [[5n48]], [[5n47]] – hScn NGAL + fibronectin<br /> | ||
**[[5nkn]] – hScn NGAL + conchicine<br /> | |||
**[[6gr0]] – hScn NGAL + petrobactin<br /> | |||
**[[3u9p]] – mScn NGAL + Fab <br /> | **[[3u9p]] – mScn NGAL + Fab <br /> | ||
**[[2lbv]] – qScn Q83 + enterobactin – NMR<br /> | **[[2lbv]] – qScn Q83 + enterobactin – NMR<br /> | ||