2vel: Difference between revisions
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==Structure-based enzyme engineering efforts with an inactive monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties== | |||
<StructureSection load='2vel' size='340' side='right' caption='[[2vel]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2vel' size='340' side='right' caption='[[2vel]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iih|1iih]], [[1kv5|1kv5]], [[1tpf|1tpf]], [[1trd|1trd]], [[1tsi|1tsi]], [[1tti|1tti]], [[1ttj|1ttj]], [[2j24|2j24]], [[2j27|2j27]], [[2v2c|2v2c]], [[2v2d|2v2d]], [[2v2h|2v2h]], [[3tim|3tim]], [[1ag1|1ag1]], [[1dkw|1dkw]], [[1iig|1iig]], [[1ml1|1ml1]], [[1mss|1mss]], [[1mtm|1mtm]], [[1tpd|1tpd]], [[1tpe|1tpe]], [[1tri|1tri]], [[2v0t|2v0t]], [[2v5l|2v5l]], [[4tim|4tim]], [[5tim|5tim]], [[6tim|6tim]], [[2vei|2vei]], [[2vek|2vek]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1iih|1iih]], [[1kv5|1kv5]], [[1tpf|1tpf]], [[1trd|1trd]], [[1tsi|1tsi]], [[1tti|1tti]], [[1ttj|1ttj]], [[2j24|2j24]], [[2j27|2j27]], [[2v2c|2v2c]], [[2v2d|2v2d]], [[2v2h|2v2h]], [[3tim|3tim]], [[1ag1|1ag1]], [[1dkw|1dkw]], [[1iig|1iig]], [[1ml1|1ml1]], [[1mss|1mss]], [[1mtm|1mtm]], [[1tpd|1tpd]], [[1tpe|1tpe]], [[1tri|1tri]], [[2v0t|2v0t]], [[2v5l|2v5l]], [[4tim|4tim]], [[5tim|5tim]], [[6tim|6tim]], [[2vei|2vei]], [[2vek|2vek]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vel OCA], [http://pdbe.org/2vel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vel RCSB], [http://www.ebi.ac.uk/pdbsum/2vel PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vel OCA], [http://pdbe.org/2vel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vel RCSB], [http://www.ebi.ac.uk/pdbsum/2vel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vel ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2vel_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2vel_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||