2q6t: Difference between revisions
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|PDB= 2q6t |SIZE=350|CAPTION= <scene name='initialview01'>2q6t</scene>, resolution 2.90Å | |PDB= 2q6t |SIZE=350|CAPTION= <scene name='initialview01'>2q6t</scene>, resolution 2.90Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= dnab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus]) | |GENE= dnab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271 Thermus aquaticus]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q6t OCA], [http://www.ebi.ac.uk/pdbsum/2q6t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q6t RCSB]</span> | |||
}} | }} | ||
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[[Category: Eliason, W K.]] | [[Category: Eliason, W K.]] | ||
[[Category: Steitz, T A.]] | [[Category: Steitz, T A.]] | ||
[[Category: dnab]] | [[Category: dnab]] | ||
[[Category: helicase]] | [[Category: helicase]] | ||
[[Category: replication]] | [[Category: replication]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:45:33 2008'' | ||
Revision as of 04:45, 31 March 2008
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| , resolution 2.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | dnab (Thermus aquaticus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the Thermus aquaticus DnaB monomer
OverviewOverview
The ring-shaped hexameric DnaB helicase unwinds duplex DNA at the replication fork of eubacteria. We have solved the crystal structure of the full-length Thermus aquaticus DnaB monomer, or possibly dimer, at 2.9 A resolution. DnaB is a highly flexible two domain protein. The C-terminal domain exhibits a RecA-like core fold and contains all the conserved sequence motifs that are characteristic of the DnaB helicase family. The N-terminal domain contains an additional helical hairpin that makes it larger than previously appreciated. Several DnaB mutations that modulate its interaction with primase are found in this hairpin. The similarity in the fold of the DnaB N-terminal domain with that of the C-terminal helicase-binding domain (HBD) of the DnaG primase also includes this hairpin. Comparison of hexameric homology models of DnaB with the structure of the papillomavirus E1 helicase suggests the two helicases may function through different mechanisms despite their sharing a common ancestor.
About this StructureAbout this Structure
2Q6T is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of the Thermus aquaticus DnaB helicase monomer., Bailey S, Eliason WK, Steitz TA, Nucleic Acids Res. 2007;35(14):4728-36. Epub 2007 Jul 1. PMID:17606462
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