6ae3: Difference between revisions

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-'''Unreleased structure'''
-The entry 6ae3 is ON HOLD
+==Crystal structure of GSK3beta complexed with Morin==
+<StructureSection load='6ae3' size='340' side='right' caption='[[6ae3]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
-Authors: Kim, K.L., Cha, J.S., Kim, J.S., Ahn, J.S., Ha, N.C., Cho, H.S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ae3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AE3 FirstGlance]. <br>
-Description: Crystal structure of GSK3beta complexed with Morin
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRI:2-[2,4-BIS(OXIDANYL)PHENYL]-3,5,7-TRIS(OXIDANYL)CHROMEN-4-ONE'>MRI</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-[[Category: Ha, N.C]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ae3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ae3 OCA], [http://pdbe.org/6ae3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ae3 RCSB], [http://www.ebi.ac.uk/pdbsum/6ae3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ae3 ProSAT]</span></td></tr>
-[[Category: Ahn, J.S]]
+</table>
-[[Category: Cha, J.S]]
+== Function ==
-[[Category: Cho, H.S]]
+[[http://www.uniprot.org/uniprot/GSK3B_MOUSE GSK3B_MOUSE]] Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SFPQ at 'Thr-679' upon T-cell activation. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation.<ref>PMID:10894547</ref> <ref>PMID:15791206</ref> <ref>PMID:16543145</ref> <ref>PMID:17391670</ref> <ref>PMID:18288891</ref> <ref>PMID:20123978</ref> <ref>PMID:21295697</ref> <ref>PMID:22057101</ref>
-[[Category: Kim, J.S]]
+== References ==
-[[Category: Kim, K.L]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ahn, J S]]
+[[Category: Cha, J S]]
+[[Category: Cho, H S]]
+[[Category: Ha, N C]]
+[[Category: Kim, J S]]
+[[Category: Kim, K L]]
+[[Category: Flavonoid]]
+[[Category: Kinase]]
+[[Category: Signaling protein]]