Serpin: Difference between revisions
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<StructureSection load='2xn6' size=' | <StructureSection load='2xn6' size='350' side='right' caption='Structure of cleaved human serpin A7. Residues 32-380 (cyan), residues 381-415 (salmon) complex with thyroxine-fluoresein, ethylene glycol and Ca+2 ion (green) (PDB entry [[2xn6]])' scene='51/517379/Cv/1'> | ||
== Function == | == Function == | ||
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | '''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | ||
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**[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br /> | **[[2ach]], [[1as4]], [[3caa]] – hSer-A3<br /> | ||
**[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br /> | **[[4caa]], [[1qmn]], [[3dlw]] – hSer-A3 (mutant)<br /> | ||
**[[5om2]], [[5om3]], [[5om5]], [[5om6]], [[5om7]], [[5om8]], [[6ftp]] – hSer-A3 (mutant) + antibiotic<br /> | |||
**[[1yxa]] – mSer-A3N - mouse<br /> | **[[1yxa]] – mSer-A3N - mouse<br /> | ||
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*Serpin A6 see [[Corticosteroid-binding globulin]] | *Serpin A6 see [[Corticosteroid-binding globulin]] | ||
*Serpin A7 | *Serpin A7 or thyroxine-binding globulin | ||
**[[2riv]] – hSer-A7<br /> | **[[2riv]] – hSer-A7<br /> | ||
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**[[4yia]] - hSer-A7 + indomethacin<br /> | **[[4yia]] - hSer-A7 + indomethacin<br /> | ||
*Serpin A8 | *Serpin A8 or angiotensin-II | ||
**[[2jp8]] – hSer-A8 – NMR<br /> | **[[2jp8]] – hSer-A8 – NMR<br /> | ||
**[[2wxw]], [[ | **[[2wxw]], [[5m3x]], [[5m3y]] – hSer-A8<br /> | ||
**[[2x0b]] – hSer-A8 + renin<br /> | **[[2x0b]] – hSer-A8 + renin<br /> | ||
**[[2wxx]], [[2wxy]], [[2wy0]] – | **[[5e2q]] – hSer-A8 + DPP<br /> | ||
**[[4fys]] – hSer-A8 + CD13<br /> | |||
**[[2wxx]], [[2wxy]], [[2wy0]] – mSer-A8 – mouse<br /> | |||
**[[2wxz]], [[2wy1]] – rSer-A8 | **[[2wxz]], [[2wy1]] – rSer-A8 | ||
*Serpin A10 | *Serpin A10 or protein Z-dependent protease inhibitor | ||
**[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z | **[[4afx]], [[4aju]] – hSer-A10 (mutant)<br /> | ||
**[[3h5c]], [[3f1s]] – hSer-A10 + vitamin K-dependent protein Z<br /> | |||
**[[4ajt]] – mSer-A10 <br /> | |||
*Serpin A12 (Vaspin) | *Serpin A12 (Vaspin) | ||
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**[[4r9i]] – Ser-A18 – bee<br /> | **[[4r9i]] – Ser-A18 – bee<br /> | ||
*Serpin B1 (leukocyte elastase inhibitor) | *Serpin B1 (leukocyte elastase inhibitor) | ||
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*Serpin B4 | *Serpin B4 | ||
**[[ | **[[4zk0]] – hSer-B4<br /> | ||
*Serpin B5 (Maspin) | *Serpin B5 (Maspin) | ||
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*Ser crmA (ice inhibitor) | *Ser crmA (ice inhibitor) | ||
**[[1c8o]], [[1f0c]] – cvSer-crmA (mutant) – cowpox virus<br /> | **[[1c8o]], [[1f0c]], [[1m93]] – cvSer-crmA (mutant) – cowpox virus<br /> | ||
*Serpin E1 see [[Plasminogen activator inhibitor]] | *Serpin E1 see [[Plasminogen activator inhibitor]] | ||
*Serpin E2 | *Serpin E2 or Gila-derived nexin | ||
**[[4dy0]] – hSer-E2 + heparin | **[[4dy0]] – hSer-E2 + heparin<br /> | ||
**[[4dy7]] – hSer-E2 + thrombin<br /> | |||
*Serpin I1 (Neuroserpin) | *Serpin I1 (Neuroserpin) | ||