Protein phosphatase: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='54/540142/Cv/1' caption='Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate [[3k7v]]'> | <StructureSection load='' size='350' side='right' scene='54/540142/Cv/1' caption='Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate [[3k7v]]'> | ||
== Function == | == Function == | ||
'''Protein phosphatases''' (PP) regulate protein phosphorylation and thus are key in intracellular signal transduction processes.<br /> | '''Protein phosphatases''' (PP) or '''serine/threonine protein phosphatase''' regulate protein phosphorylation and thus are key in intracellular signal transduction processes.<br /> | ||
* '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br /> | * '''PP1''' is a serine/threonine phosphatase and is a key component of the insulin signaling pathway<ref>PMID:9609113</ref>.<br /> | ||
* '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br /> | * '''PP2A''' targets proteins in the oncogenic signaling pathways<ref>PMID:11812651</ref>. For PP2A see also [[HEAT Repeat]].<br /> | ||
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**[[2ie3]], [[2ie4]], [[2npp]], [[2nyl]], [[2nym]] – hPP2A catalytic + regulatory subunit + tumor-inducing toxin<br /> | **[[2ie3]], [[2ie4]], [[2npp]], [[2nyl]], [[2nym]] – hPP2A catalytic + regulatory subunit + tumor-inducing toxin<br /> | ||
**[[3c5w]] – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase<br /> | **[[3c5w]] – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase<br /> | ||
*Protein phosphatase 2B See [[Calcineurin]] | |||
*Protein phosphatase 2C | *Protein phosphatase 2C | ||
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**[[4yzh]] – AtPP2C (mutant) + chlorophyll-binding protein peptide<br /> | **[[4yzh]] – AtPP2C (mutant) + chlorophyll-binding protein peptide<br /> | ||
**[[3ujg]] - AtPP2C + SRK2E<br /> | **[[3ujg]] - AtPP2C + SRK2E<br /> | ||
*Protein phosphatase 4 | |||
**[[4wsf]] – PP4 regulatory subunit + Cenp-C – ''Drosophila melanogaster''<br /> | |||
*Protein phosphatase 5 | |||
**[[1wao]] – hPP5 + Mn<br /> | |||
**[[5muf]] – hPP5 <br /> | |||
**[[1a17]] – hPP5 protein-interacting domain<br /> | |||
**[[2bug]] – hPP5 protein-interacting domain (mutant) + Hsp90 peptide - NMR<br /> | |||
**[[1s95]], [[3h60]] – hPP5 catalytic domain + Mn<br /> | |||
**[[3h61]], [[3h62]], [[3h63]], [[3h64]], [[3h66]], [[3h67]], [[3h68]], [[3h69]], [[4zvz]], [[4zx2]], [[4zvz]], [[4zx2]] – hPP5 catalytic domain + inhibitor + Mn<br /> | |||
**[[5hpe]] – hPP5 catalytic domain/Hsp90 peptide + Mn<br /> | |||
**[[4ja7]], [[4ja9]] - rPP5 catalytic domain + inhibitor <br /> | |||
**[[3icf]] - yPP5 catalytic domain + Fe - yeast<br /> | |||
**[[5jjt]] – AtPP5 + Ni<br /> | |||
*Protein phosphatase | |||
**[[1g5b]] – PP + Mn – Enterobacteria phage λ<br /> | |||
**[[2pk0]] – PP + Mg – ''Streptococcus agalactiae''<br /> | |||
**[[2cm1]] – PP + Mn – ''Mycobacterium tuberculosis''<br /> | |||
**[[3pu9]] – PP + Mg – ''Sphaerobacter thermophilus''<br /> | |||
**[[5f1m]] – PP Stp1 + Mn – ''Staphylococcus aureus''<br /> | |||
**[[5jpf]] – PP Z1 + microcystin-LR + Mn – ''Candida albicans''<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||