6hh0: Difference between revisions

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'''Unreleased structure'''


The entry 6hh0 is ON HOLD
==Yeast V-ATPase transmembrane helix 7 NMR structure in DPC micelles==
 
<StructureSection load='6hh0' size='340' side='right' caption='[[6hh0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6hh0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HH0 FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hh0 OCA], [http://pdbe.org/6hh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hh0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hh0 ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/VPH1_YEAST VPH1_YEAST]] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Hohlweg, W]]
[[Category: Wagner, G]]
[[Category: Zangger, K]]
[[Category: Atpasse]]
[[Category: Dpc micelle]]
[[Category: Membrane protein]]
[[Category: Nmr spectroscopy]]
[[Category: Transmembrane helix]]

Revision as of 10:41, 12 September 2018

Yeast V-ATPase transmembrane helix 7 NMR structure in DPC micellesYeast V-ATPase transmembrane helix 7 NMR structure in DPC micelles

Structural highlights

6hh0 is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[VPH1_YEAST] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.[1] [2] [3]

References

  1. ↑ Kawasaki-Nishi S, Nishi T, Forgac M. Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation. J Biol Chem. 2001 May 25;276(21):17941-8. Epub 2001 Mar 2. PMID:11278748 doi:http://dx.doi.org/10.1074/jbc.M010790200
  2. ↑ Manolson MF, Proteau D, Jones EW. Evidence for a conserved 95-120 kDa subunit associated with and essential for activity of V-ATPases. J Exp Biol. 1992 Nov;172:105-12. PMID:1491220
  3. ↑ Leng XH, Manolson MF, Liu Q, Forgac M. Site-directed mutagenesis of the 100-kDa subunit (Vph1p) of the yeast vacuolar (H+)-ATPase. J Biol Chem. 1996 Sep 13;271(37):22487-93. PMID:8798414
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