6e48: Difference between revisions

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'''Unreleased structure'''


The entry 6e48 is ON HOLD  until Paper Publication
==Crystal Structure of the Murine Norovirus VP1 P domain in complex with the CD300lf Receptor and Lithocholic Acid==
 
<StructureSection load='6e48' size='340' side='right' caption='[[6e48]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors: Nelson, C.A., Fremont, D.H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6e48]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E48 FirstGlance]. <br>
Description: Protruding Domain of Murine Norovirus in Complex with the CD300lf Receptor and Lithocholic Acid
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OA:(3BETA,5BETA,14BETA,17ALPHA)-3-HYDROXYCHOLAN-24-OIC+ACID'>4OA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lq6|3lq6]]</td></tr>
[[Category: Fremont, D.H]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e48 OCA], [http://pdbe.org/6e48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e48 RCSB], [http://www.ebi.ac.uk/pdbsum/6e48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e48 ProSAT]</span></td></tr>
[[Category: Nelson, C.A]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CLM1_MOUSE CLM1_MOUSE]] Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.<ref>PMID:14662855</ref> <ref>PMID:17438331</ref> <ref>PMID:18097021</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Fremont, D H]]
[[Category: Nelson, C A]]
[[Category: Bile acid]]
[[Category: Capsid protein]]
[[Category: Clm-1]]
[[Category: Clm1]]
[[Category: Cmrf-35-like molecule-1]]
[[Category: Dir2]]
[[Category: Igsf13]]
[[Category: Irem1]]
[[Category: Lca]]
[[Category: Lmir3]]
[[Category: Myeloid receptor]]
[[Category: Norovirus]]
[[Category: Pigr3]]
[[Category: Protruding domain]]
[[Category: Viral protein]]

Revision as of 10:37, 12 September 2018

Crystal Structure of the Murine Norovirus VP1 P domain in complex with the CD300lf Receptor and Lithocholic AcidCrystal Structure of the Murine Norovirus VP1 P domain in complex with the CD300lf Receptor and Lithocholic Acid

Structural highlights

6e48 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CLM1_MOUSE] Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.[1] [2] [3]

References

  1. ↑ Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15;171(12):6541-8. PMID:14662855
  2. ↑ Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Oki T, Shibata F, Kumagai H, Nakajima H, Maeda-Yamamoto M, Hauchins JP, Tybulewicz VL, Takai T, Kitamura T. Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3. J Biol Chem. 2007 Jun 22;282(25):17997-8008. Epub 2007 Apr 16. PMID:17438331 doi:http://dx.doi.org/10.1074/jbc.M701100200
  3. ↑ Can I, Tahara-Hanaoka S, Hitomi K, Nakano T, Nakahashi-Oda C, Kurita N, Honda S, Shibuya K, Shibuya A. Caspase-independent cell death by CD300LF (MAIR-V), an inhibitory immunoglobulin-like receptor on myeloid cells. J Immunol. 2008 Jan 1;180(1):207-13. PMID:18097021

6e48, resolution 1.80Å

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