6c6q: Difference between revisions

Revision as of 10:34, 12 September 2018

Crystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf ReceptorCrystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf Receptor

Structural highlights

6c6q is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	3lq6, 6e47, 6e48, 6c74
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CLM1_MOUSE] Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.^[1] ^[2] ^[3]

References

↑ Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15;171(12):6541-8. PMID:14662855
↑ Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Oki T, Shibata F, Kumagai H, Nakajima H, Maeda-Yamamoto M, Hauchins JP, Tybulewicz VL, Takai T, Kitamura T. Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3. J Biol Chem. 2007 Jun 22;282(25):17997-8008. Epub 2007 Apr 16. PMID:17438331 doi:http://dx.doi.org/10.1074/jbc.M701100200
↑ Can I, Tahara-Hanaoka S, Hitomi K, Nakano T, Nakahashi-Oda C, Kurita N, Honda S, Shibuya K, Shibuya A. Caspase-independent cell death by CD300LF (MAIR-V), an inhibitory immunoglobulin-like receptor on myeloid cells. J Immunol. 2008 Jan 1;180(1):207-13. PMID:18097021

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OCA

[1] Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15;171(12):6541-8. PMID:14662855

[2] Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Oki T, Shibata F, Kumagai H, Nakajima H, Maeda-Yamamoto M, Hauchins JP, Tybulewicz VL, Takai T, Kitamura T. Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3. J Biol Chem. 2007 Jun 22;282(25):17997-8008. Epub 2007 Apr 16. PMID:17438331 doi:http://dx.doi.org/10.1074/jbc.M701100200

[3] Can I, Tahara-Hanaoka S, Hitomi K, Nakano T, Nakahashi-Oda C, Kurita N, Honda S, Shibuya K, Shibuya A. Caspase-independent cell death by CD300LF (MAIR-V), an inhibitory immunoglobulin-like receptor on myeloid cells. J Immunol. 2008 Jan 1;180(1):207-13. PMID:18097021

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6c6q is ON HOLD  until Paper Publication
+==Crystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf Receptor==
+<StructureSection load='6c6q' size='340' side='right' caption='[[6c6q]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6c6q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C6Q FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lq6|3lq6]], [[6e47|6e47]], [[6e48|6e48]], [[6c74|6c74]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c6q OCA], [http://pdbe.org/6c6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c6q RCSB], [http://www.ebi.ac.uk/pdbsum/6c6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c6q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CLM1_MOUSE CLM1_MOUSE]] Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.<ref>PMID:14662855</ref> <ref>PMID:17438331</ref> <ref>PMID:18097021</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Fremont, D H]]
+[[Category: Nelson, C A]]
+[[Category: Capsid protein]]
+[[Category: Cd300lf]]
+[[Category: Clm-1]]
+[[Category: Clm1]]
+[[Category: Cmrf-35-like molecule-1]]
+[[Category: Dir2]]
+[[Category: Ig-v like]]
+[[Category: Igsf13]]
+[[Category: Irem1]]
+[[Category: Lmir3]]
+[[Category: Myeloid receptor]]
+[[Category: Norovirus]]
+[[Category: Pigr3]]
+[[Category: Protruding domain]]
+[[Category: Viral protein-lipid binding protein complex]]
+[[Category: Vp1]]

6c6q: Difference between revisions

Revision as of 10:34, 12 September 2018

Crystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf ReceptorCrystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf Receptor

Structural highlights

Function

References

Contents

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6c6q: Difference between revisions

Revision as of 10:34, 12 September 2018

Crystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf ReceptorCrystal Structure of the Murine Norovirus VP1 P Domain in complex with the CD300lf Receptor

Structural highlights

Function

References

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