6el3: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
m Protected "6el3" [edit=sysop:move=sysop]
No edit summary
Line 1: Line 1:
'''Unreleased structure'''


The entry 6el3 is ON HOLD
==Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP==
 
<StructureSection load='6el3' size='340' side='right' caption='[[6el3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6el3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EL3 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Delta(4)-3-oxosteroid_5-beta-reductase Delta(4)-3-oxosteroid 5-beta-reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.3 1.3.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6el3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6el3 OCA], [http://pdbe.org/6el3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6el3 RCSB], [http://www.ebi.ac.uk/pdbsum/6el3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6el3 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/VEP1_ARATH VEP1_ARATH]] Involved in vascular strand development. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 21-acetyl cortexone, 2-cyclohexenone, but-1-en-3-one, ethyl acrylate, ethylmethacrylate, cortisone and canarigenone as substrates, lower activity with 3-methyl-2-cyclohexenone and 3,5,5-trimethyl-2-cyclohexenone as substrate, and no activity with canarigenin, canarigenin digitoxoside and pregnenolone. May be involved in the formation of 5-beta phytoecdysteroids.<ref>PMID:11917087</ref> <ref>PMID:19166903</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Egerer-Sieber, C]]
[[Category: Muller, Y A]]
[[Category: Schmidt, K]]
[[Category: Homodimer]]
[[Category: Nadp binding site]]
[[Category: Oxidoreductase]]

Revision as of 13:11, 5 September 2018

Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADPStructure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP

Structural highlights

6el3 is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
NonStd Res:
Activity:Delta(4)-3-oxosteroid 5-beta-reductase, with EC number 1.3.1.3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[VEP1_ARATH] Involved in vascular strand development. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 21-acetyl cortexone, 2-cyclohexenone, but-1-en-3-one, ethyl acrylate, ethylmethacrylate, cortisone and canarigenone as substrates, lower activity with 3-methyl-2-cyclohexenone and 3,5,5-trimethyl-2-cyclohexenone as substrate, and no activity with canarigenin, canarigenin digitoxoside and pregnenolone. May be involved in the formation of 5-beta phytoecdysteroids.[1] [2]

References

  1. ↑ Jun JH, Ha CM, Nam HG. Involvement of the VEP1 gene in vascular strand development in Arabidopsis thaliana. Plant Cell Physiol. 2002 Mar;43(3):323-30. PMID:11917087
  2. ↑ Herl V, Fischer G, Reva VA, Stiebritz M, Muller YA, Muller-Uri F, Kreis W. The VEP1 gene (At4g24220) encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4,5-steroid 5beta-reductase activity in Arabidopsis thaliana L. Biochimie. 2009 Apr;91(4):517-25. doi: 10.1016/j.biochi.2008.12.005. Epub 2009, Jan 10. PMID:19166903 doi:http://dx.doi.org/10.1016/j.biochi.2008.12.005

6el3, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=6el3&oldid=2943853"