2pkv: Difference between revisions
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|PDB= 2pkv |SIZE=350|CAPTION= <scene name='initialview01'>2pkv</scene>, resolution 1.60Å | |PDB= 2pkv |SIZE=350|CAPTION= <scene name='initialview01'>2pkv</scene>, resolution 1.60Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[115d|115D]], [[1vj4|1VJ4]], [[2pl4|2PL4]], [[2pl8|2PL8]], [[2plb|2PLB]], [[2plo|2PLO]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkv OCA], [http://www.ebi.ac.uk/pdbsum/2pkv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2pkv RCSB]</span> | |||
}} | }} | ||
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[[Category: high pressure]] | [[Category: high pressure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:37:16 2008'' | ||
Revision as of 04:37, 31 March 2008
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| , resolution 1.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Related: | 115D, 1VJ4, 2PL4, 2PL8, 2PLB, 2PLO
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
D-(GGTATACC) ambient pressure
OverviewOverview
The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
About this StructureAbout this Structure
2PKV is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642
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