6fh6: Difference between revisions
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<StructureSection load='6fh6' size='340' side='right' caption='[[6fh6]], [[Resolution|resolution]] 2.08Å' scene=''> | <StructureSection load='6fh6' size='340' side='right' caption='[[6fh6]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6fh6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FH6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[6fh6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FH6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FH6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D8Q:~{N}-(2-azanylethyl)-1-methyl-6-oxidanylidene-pyridine-3-carboxamide'>D8Q</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D8Q:~{N}-(2-azanylethyl)-1-methyl-6-oxidanylidene-pyridine-3-carboxamide'>D8Q</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fgt|6fgt]], [[6fgu|6fgu]], [[6fg6|6fg6]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fgt|6fgt]], [[6fgu|6fgu]], [[6fg6|6fg6]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAZ2B, KIAA1476 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fh6 OCA], [http://pdbe.org/6fh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fh6 RCSB], [http://www.ebi.ac.uk/pdbsum/6fh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fh6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fh6 OCA], [http://pdbe.org/6fh6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fh6 RCSB], [http://www.ebi.ac.uk/pdbsum/6fh6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fh6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Caflisch, A]] | [[Category: Caflisch, A]] | ||
[[Category: Lolli, G]] | [[Category: Lolli, G]] | ||
Latest revision as of 11:01, 29 August 2018
Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 1Crystal Structure of BAZ2B bromodomain in complex with 1-methylpyridinone compound 1
Structural highlights
Function[BAZ2B_HUMAN] May play a role in transcriptional regulation interacting with ISWI. Publication Abstract from PubMedThe bromodomain-containing protein BAZ2A is a validated target in prostate cancer, while the function of its paralog BAZ2B is still undefined. The bromodomains of BAZ2A and BAZ2B have a very similar binding site for their natural ligand, the acetylated lysine side chain. Here, we present an analysis of the binding modes of eight compounds belonging to three distinct chemical classes. For all compounds, the moiety mimicking the natural ligand makes essentially identical interactions in the BAZ2A and BAZ2B bromodomains. In contrast, the rest of the molecule is partially solvent exposed and shows different orientations and interactions in the two bromodomains. Some of these differences could be exploited for designing selective inhibitors within the BAZ2 bromodomain subfamily. Structural Analysis of Small Molecule Binding to the BAZ2A and BAZ2B Bromodomains.,Dalle Vedove A, Spiliotopoulos D, D'Agostino VG, Marchand JR, Unzue A, Nevado C, Lolli G, Caflisch A ChemMedChem. 2018 May 17. doi: 10.1002/cmdc.201800234. PMID:29770599[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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