6h02: Difference between revisions

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-'''Unreleased structure'''
-The entry 6h02 is ON HOLD  until Jan 06 2020
+==Crystal structure of human Mediator subunit MED23==
+<StructureSection load='6h02' size='340' side='right' caption='[[6h02]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6h02]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H02 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h02 OCA], [http://pdbe.org/6h02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h02 RCSB], [http://www.ebi.ac.uk/pdbsum/6h02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h02 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/MED23_HUMAN MED23_HUMAN]] Autosomal recessive non-syndromic intellectual disability. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/MED23_HUMAN MED23_HUMAN]] Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10353252</ref> <ref>PMID:14759369</ref> <ref>PMID:16595664</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans. We generated sur2-/- embryonic stem cells to analyze its function as a mammalian Mediator component. Our results show that Sur2 forms a subcomplex of the Mediator with two other subunits, TRAP/Med100 and 95. Knock-out of Sur2 prevents activation by E1A-CR3 and the mitogen-activated protein kinase-regulated ETS transcription factor Elk-1, but not by multiple other transcription factors. These results imply that specific activation domains stimulate transcription by binding to distinct Mediator subunits. Activation by E1A and Elk-1 requires recruitment of Mediator to a promoter by binding to its Sur2 subunit.
-Authors:
+Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.,Stevens JL, Cantin GT, Wang G, Shevchenko A, Shevchenko A, Berk AJ Science. 2002 Apr 26;296(5568):755-8. Epub 2002 Apr 4. PMID:11934987<ref>PMID:11934987</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6h02" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Clantin, B]]
+[[Category: Monte, D]]
+[[Category: Villeret, V]]
+[[Category: Complex]]
+[[Category: Human]]
+[[Category: Mediator]]
+[[Category: Subunit]]
+[[Category: Transcription]]