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==Crystal structure of Human CSNK1A1 with A86== | |||
<StructureSection load='6gzd' size='340' side='right' caption='[[6gzd]], [[Resolution|resolution]] 2.28Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gzd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZD FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LCI:[4-[[4-[5-(cyclopropylmethyl)-1-methyl-pyrazol-4-yl]-5-fluoranyl-pyrimidin-2-yl]amino]cyclohexyl]azanium'>LCI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gzd OCA], [http://pdbe.org/6gzd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gzd RCSB], [http://www.ebi.ac.uk/pdbsum/6gzd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gzd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/KC1A_HUMAN KC1A_HUMAN]] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).<ref>PMID:11955436</ref> <ref>PMID:1409656</ref> <ref>PMID:18305108</ref> <ref>PMID:23902688</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Ben-Neriah, Y]] | |||
[[Category: Fink, A]] | [[Category: Fink, A]] | ||
[[Category: | [[Category: Minzel, W]] | ||
[[Category: Snir-Alkalay, I]] | [[Category: Snir-Alkalay, I]] | ||
[[Category: Vacca, J]] | [[Category: Vacca, J]] | ||
[[Category: Venkatachalam, A]] | [[Category: Venkatachalam, A]] | ||
[[Category: Casein kinase]] | |||
[[Category: Ckia]] | |||
[[Category: Kinase inhibitor]] | |||
[[Category: Transferase]] | |||