6edd: Difference between revisions

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'''Unreleased structure'''


The entry 6edd is ON HOLD
==Crystal structure of a GNAT Superfamily PA3944 acetyltransferase in complex with CoA (P1 space group)==
 
<StructureSection load='6edd' size='340' side='right' caption='[[6edd]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
Authors: Czub, M.P., Porebski, P.J., Majorek, K.A., Satchell, K.J., Joachimiak, A., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6edd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EDD FirstGlance]. <br>
Description: Crystal structure of a GNAT Superfamily PA3944 acetyltransferase in complex with CoA (P1 space group)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
[[Category: Satchell, K.J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6edd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6edd OCA], [http://pdbe.org/6edd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6edd RCSB], [http://www.ebi.ac.uk/pdbsum/6edd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6edd ProSAT]</span></td></tr>
[[Category: Porebski, P.J]]
</table>
[[Category: Czub, M.P]]
== Function ==
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
[[http://www.uniprot.org/uniprot/ATSE3_PSEAE ATSE3_PSEAE]] Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers the peptide Asp-Phe methyl ester (or aspartame) and the peptide antibiotics polymyxin B and colistin. Other substrates like dopamine, serotonin, puromycin, chloramphenicol, D-glucosamine, glycine and N-alpha-acetyl-L-glutamine are used and displayed lower activity.<ref>PMID:23184347</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Structural genomic]]
[[Category: Czub, M P]]
[[Category: Joachimiak, A]]
[[Category: Majorek, K A]]
[[Category: Minor, W]]
[[Category: Minor, W]]
[[Category: Joachimiak, A]]
[[Category: Porebski, P J]]
[[Category: Majorek, K.A]]
[[Category: Satchell, K J]]
[[Category: Acetyltransferase]]
[[Category: Csgid]]
[[Category: Gnat]]
[[Category: Pa3944]]
[[Category: Transferase]]

Revision as of 09:09, 22 August 2018

Crystal structure of a GNAT Superfamily PA3944 acetyltransferase in complex with CoA (P1 space group)Crystal structure of a GNAT Superfamily PA3944 acetyltransferase in complex with CoA (P1 space group)

Structural highlights

6edd is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
NonStd Res:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ATSE3_PSEAE] Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers the peptide Asp-Phe methyl ester (or aspartame) and the peptide antibiotics polymyxin B and colistin. Other substrates like dopamine, serotonin, puromycin, chloramphenicol, D-glucosamine, glycine and N-alpha-acetyl-L-glutamine are used and displayed lower activity.[1]

References

  1. ↑ Kuhn ML, Majorek KA, Minor W, Anderson WF. Broad-substrate screen as a tool to identify substrates for bacterial Gcn5-related N-acetyltransferases with unknown substrate specificity. Protein Sci. 2013 Feb;22(2):222-30. doi: 10.1002/pro.2199. Epub 2012 Dec 17. PMID:23184347 doi:http://dx.doi.org/10.1002/pro.2199

6edd, resolution 1.55Å

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