6df3: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6df3 is ON HOLD  until Paper Publication
+==Crystal structure of ternary complex of IL-24 with soluble receptors IL-22RA and IL-20RB==
+<StructureSection load='6df3' size='340' side='right' caption='[[6df3]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-Authors: Lubkowski, J., Wlodawer, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6df3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DF3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DF3 FirstGlance]. <br>
-Description: Crystal structure of ternary complex of IL-24 with soluble receptors IL-22RA and IL-20RB
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6df3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6df3 OCA], [http://pdbe.org/6df3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6df3 RCSB], [http://www.ebi.ac.uk/pdbsum/6df3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6df3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/I22R1_HUMAN I22R1_HUMAN]] Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.<ref>PMID:11035029</ref> <ref>PMID:11564763</ref> <ref>PMID:11706020</ref> <ref>PMID:12351624</ref> <ref>PMID:12941841</ref> <ref>PMID:17204547</ref>  [[http://www.uniprot.org/uniprot/I20RB_HUMAN I20RB_HUMAN]] The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. [[http://www.uniprot.org/uniprot/IL24_HUMAN IL24_HUMAN]] Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Lubkowski, J]]
 [[Category: Wlodawer, A]]
-[[Category: Lubkowski, J]]
+[[Category: Cell signaling]]
+[[Category: Cytokine]]
+[[Category: Jak-stat pathway]]
+[[Category: Ternary complex]]