2ow3: Difference between revisions
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|PDB= 2ow3 |SIZE=350|CAPTION= <scene name='initialview01'>2ow3</scene>, resolution 2.80Å | |PDB= 2ow3 |SIZE=350|CAPTION= <scene name='initialview01'>2ow3</scene>, resolution 2.80Å | ||
|SITE= <scene name='pdbsite=AC1:Bim+Binding+Site+For+Residue+A+387'>AC1</scene> and <scene name='pdbsite=AC2:Bim+Binding+Site+For+Residue+B+387'>AC2</scene> | |SITE= <scene name='pdbsite=AC1:Bim+Binding+Site+For+Residue+A+387'>AC1</scene> and <scene name='pdbsite=AC2:Bim+Binding+Site+For+Residue+B+387'>AC2</scene> | ||
|LIGAND= <scene name='pdbligand=BIM:'>BIM</scene> | |LIGAND= <scene name='pdbligand=BIM:BIS-(INDOLE)MALEIMIDE+PYRIDINOPHANE'>BIM</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] </span> | ||
|GENE= GSK3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= GSK3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ow3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ow3 OCA], [http://www.ebi.ac.uk/pdbsum/2ow3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ow3 RCSB]</span> | |||
}} | }} | ||
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[[Category: Ye, H.]] | [[Category: Ye, H.]] | ||
[[Category: Zhang, H C.]] | [[Category: Zhang, H C.]] | ||
[[Category: kinase-inhibitor complex]] | [[Category: kinase-inhibitor complex]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:24:00 2008'' | ||
Revision as of 04:24, 31 March 2008
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| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | and | ||||||
| Ligands: | , | ||||||
| Gene: | GSK3B (Homo sapiens) | ||||||
| Activity: | [Tau_protein_kinase [Tau protein] kinase], with EC number 2.7.11.26 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor
OverviewOverview
Novel bis(indolyl)maleimide pyridinophanes 3, 9a, 9b, 10a, 10b, and 11 were prepared by cobalt-mediated [2+2+2] cycloaddition of an appropriate alpha,omega-diyne with an N,N-dialkylcyanamide. These macrocyclic heterophanes were found to be potent, selective inhibitors of glycogen synthase kinase-3beta. An X-ray structure of a co-crystal of GSK-3beta and 3 (IC(50)=3nM) depicts the hydrogen bonding and hydrophobic interactions in the ATP-binding pocket of this serine/threonine protein kinase.
About this StructureAbout this Structure
2OW3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3., Zhang HC, Bonaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE, Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25. PMID:17350261 [[Category: [Tau protein] kinase]]
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