6e68: Difference between revisions
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==NAMPT co-crystal with inhibitor compound 2== | |||
<StructureSection load='6e68' size='340' side='right' caption='[[6e68]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6e68]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E68 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HVM:(2E)-N-{4-[1-(3-aminobenzene-1-carbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide'>HVM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr> | ||
[[Category: Neumann, C | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e68 OCA], [http://pdbe.org/6e68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e68 RCSB], [http://www.ebi.ac.uk/pdbsum/6e68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e68 ProSAT]</span></td></tr> | ||
[[Category: Waight, A | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Nicotinamide phosphoribosyltransferase]] | |||
[[Category: Neumann, C S]] | |||
[[Category: Waight, A B]] | |||
[[Category: Anti-tumor]] | |||
[[Category: Antibody-drug conjugate]] | |||
[[Category: Cytosolic protein]] | |||
[[Category: Cytotoxic]] | |||
[[Category: Transferase-inhibitor complex]] | |||
Revision as of 00:50, 10 August 2018
NAMPT co-crystal with inhibitor compound 2NAMPT co-crystal with inhibitor compound 2
Structural highlights
Function[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). |
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