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| <StructureSection load='3ox8' size='350' side='right' caption='Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) [[3ox8]]' scene='45/457390/Cv/1'> | | <StructureSection load='' size='350' side='right' caption='Human MHC class I antigen (cyan) with β 2-microglobulin (green) and peptide from Hepatitis virus (deeppink) [[3ox8]]' scene='45/457390/Cv/1'> |
| == Function == | | == Function == |
| ''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> | | ''' Major Histocompatibility Complex''' (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br /> |
Revision as of 03:02, 7 August 2018
Function Major Histocompatibility Complex (MHC) are part of the cell immune system. MHC molecules display antigens on the host cell’s surface. T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.
Structural highlights.
The [3]. Water molecules shown as red spheres.
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3D structures of MHC3D structures of MHC
Updated on 07-August-2018
{"openlevels":0}
- MHC I
- MHC I binary complex
- 1zs8 - mMHC I + β-2-microglobulin – mouse
- 2hla, 3hla, 1hla - hMHC I + β-2-microglobulin – human
- 3p73, 3p77 - cMHC I + β-2-microglobulin – chicken
- MHC I ternary complex
- 4d0b, 3bew, 2yez, 5ad0, 4d0c, 3bev, 4cvx – cMHC I α + β-2-microglobulin + peptide
- 3kpn, 3kpo – hMHC I B + β-2-microglobulin + peptide
- 3bev, 1kpr, 1k5n, 3nfn, 3mr9, 3mrb, 3mrc, 3mrd, 3mre, 3mrf, 3mrg, 3mrh, 3mri, 3mrj, 3mrk, 3mrl, 3mrm, 3mrn, 3mro, 3mrp, 3mrq, 3mrr, 3ox8, 3oxr, 3oxs, 2xpg, 3pwj, 3pwl, 3pwn, 3pwp, 2x70, 3o3a, 3o3b, 3o3d, 3o3e, 3lv3, 3ln4, 3ln5, 3myj, 3i6l, 3lkn, 3lko, 3lkp, 3lkq, 3lkr, 3lks, 3hpj, 3i6g, 3i6k, 3mgo, 3mgt, 3l3d, 3l3g, 3l3i, 3l3j, 3l3k, 2x4n, 2x4o, 2x4p, 2x4q, 2x4r, 2x4s, 2x4t, 2x4u, 3lka, 3h7b, 3kpl, 3kpm, 3kpn, 3kpo, 3kpp, 3kpq, 3kpr, 3kps, 3giv, 3hcv, 3d18, 3dtx, 3czf, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3d25, 3bvn, 3dx6, 3dx7, 3dx8, 3dxa, 3bo8, 3bp4, 3bp7, 3bgm, 3bh8, 3bh9, 3bhb, 3b3i, 3b6s, 2rfx, 3bze, 3bzf, 3bw9, 3bwa, 3c9n, 2v2w, 2v2x, 2gt9, 2gtw, 2gtz, 2guo, 2nw3, 2fyy, 2fz3, 2hn7, 2cik, 2git, 2hjk, 2hjl, 2h6p, 2d31, 2c7u, 2bck, 2a83, 2axf, 2axg, 2bvo, 2bvp, 2bvq, 1s8d, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1s7q, 1zsd, 2bsr, 2bss, 2bst, 1zhk, 1zhl, 1tvb, 1tvh, 1xr8, 1xr9, 1w0v, 1w0w, 1xh3, 1uxs, 1uxw, 1s9w, 1s9x, 1s9y, 1q94, 1qvo, 1n2r, 1ogt, 1qew, 1jge, 1k5n, 1i7r, 1i7t, 1i7u, 1jf1, 1jht, 1i4f, 1e27, 1e28, 1i1y, 1i1f, 1qqd, 1mhe, 1b0g, 1a9b, 1a9e, 1a1m, 1a1n, 1a1o, 1tmc, 2clr, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hsb, 1hsa, 3to2, 2vab - hMHC I α + β-2-microglobulin + peptide
- 1ktl, 3kww, 3h9h, 3ixa, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3ft2, 3ft3, 3ft4, 2av1, 2av7, 1cg9, 1m05, 1m6o, 1kpr, 1ktl - hMHC I α (mutant) + β-2-microglobulin + peptide
- 1syv, 1n2r, 1syv - hMHC I + β-2-microglobulin + hMHC II peptide
- 1kjv, 1kjm, 1ed3 – MHC I α + β-2-microglobulin + peptide - rat
- 2oi9 - mMHC I α + T cell receptor + peptide
- 1kbg, 3l3h, 3ftg, 3e6f, 3ecb, 3ch1, 3cch, 3cc5, 3cpl, 2zsv, 2zsw, 2zok, 2zol, 3buy, 2ve6, 2e7l, 2fo4, 2cii, 2fwo, 2f74, 1zt1, 1zt7, 1vgk, 1yn6, 1yn7, 1zhb, 1wbx, 1wby, 1wbz, 1rjy, 1rjz, 1rk0, 1rk1, 1t0m, 1t0n, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1lk2, 1kpu, 1kpv, 1n3n, 1nan, 1n59, 1n5a, 1ffn, 1ffo, 1ffp, 1g7p, 1g7q, 1lek, 1leg, 1inq, 1juf, 1k8d, 1jpf, 1jpg, 1fg2, 1qlf, 1bz9, 1kbg, 1hoc, 2mha, 1vad, 1vac, 3roo, 3quk, 3qul, 3rol, 3tbs, 3tbt, 3tbv, 3tbw, 4nsk, 3tby - mMHC I + β-2-microglobulin + peptide
- 2qri - mMHC I/β-2-microglobulin/peptide
- 2qrs, 2qrt - mMHC I (mutant)/β-2-microglobulin/peptide
- 1mhc, 2clv, 2clz, 1fzj, 1fzk, 1fzm, 1fzo, 1ddh - mMHC I (mutant) + β-2-microglobulin + peptide
- 3e2h, 3e3q, 2e7l - mMHC I α (mutant) + T cell receptor + peptide
- 1nez - mMHC I + β-2-microglobulin + CD8 α chain
- 3rwc, 3rwd, 3rwe, 3rwf, 3rwg, 3rwh, 3rwi, 3rwj, 4zfz - MHC I + β-2-microglobulin + peptide – Rhesus macaque
- 3qq3, 3qq4 - MHC I + β-2-microglobulin + peptide - pig
- MHC I quaternary complex
- 3qdg, 3qdj, 3qdm, 3qeq, 3mv7, 3mv9, 3h9s, 3gsn, 3d39, 3d3v, 3ffc, 2vlj, 2vlk, 2vll, 2vlr, 2j8u, 2p5e, 2p5w, 2pye, 2gj6, 2f54, 2esv, 2bnq, 2bnr, 1lp9, 1oga, 1mi5, 1qrn - hMHC I α + T cell receptor + β-2-microglobulin + peptide
- 3kxf, 3mv8, 2jcc, 2uwe - hMHC I α (mutant) + T cell receptor + β-2-microglobulin + peptide
- 2f53 - hMHC I α + T cell receptor + β-2-microglobulin (mutant) + peptide
- 1p7q, 1im9 - hMHC I α + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide
- 2dyp - hMHC I α (mutant) + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide
- 3qzw, 3dmm, 1bqh, 1akj - hMHC I α + β-2-microglobulin + CD8 α + peptide
- 1im3 - hMHC I α + β-2-microglobulin + cytomegalovirus protein US2 + peptide
- 3cii, 3cdg - hMHC I α + β-2-microglobulin + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide
- 3hae, 3gjf, 3cvh, 1w72 - hMHC I α + β-2-microglobulin + antibody + peptide
- 1g6r, 2ckb, 3pqy, 2z31, 1nam, 1mwa, 1g6r, 2ckb - mMHC I + T cell receptor + β-2-microglobulin + peptide
- 2oi9 - mMHC I (mutant) + T cell receptor + β-2-microglobulin + peptide
- 1p1z, 1p4l, 1qo3 - mMHC I + β-2-microglobulin + natural killer cell receptor LY49C + peptide
- 3c8k - mMHC I (mutant) + β-2-microglobulin + natural killer cell receptor LY49C + peptide
- MHC II
- MHC II binary complex
- 1h15 - hMHC II α+β + DNA polymerase peptide
- 1fv1 - hMHC II α+β + myelin basic protein
- 3o6f, 2wbj - hMHC II α+β + T cell receptor
- 3l6f, 3c5j, 2q6w, 2fse, 1t5w, 1s9v, 1uvq, 1h15, 1fv1 – hMHC II α+β + peptide
- 1dlh - hMHC II α+β + enterotoxin
- 3c5z, 3c60, 3c6l - mMHC II α+β + T cell receptor
- 1r5v, 1k2d, 1muj, 1kt2, 1ktd, 1f3j, 1es0, 1iak, 1iea, 1ieb, 1f3j - mMHC II α+β + peptide
- 1aqd - mMHC II α+β + MHC I peptide
- 1r5w, 1i3r - mMHC II α+β (mutant) + peptide
- MHC II ternary complex
- 1zgl, 1j8h, 1fyt - hMHC II α+β + T cell receptor + peptide
- 2iam, 2ian, 1ymm – hMHC II α+β + T cell receptor (mutant) + peptide
- 2ipk, 2g9h, 1pyw, 1jwm, 1jws, 1jwu, 1klg, 1klu, 1hxy, 1d5m, 1d5x, 1d5z, 1d6e, 2seb, 1seb - hMHC II α+β + enterotoxin + peptide
- 1sje, 1sjh, 1t5x, 1lo5 - hMHC II α+β + enterotoxin (mutant) + peptide
- 1r5i - hMHC II α+β + mycoplasma arthritidis mitogen+ peptide
- 2oje - mMHC II α+β + mycoplasma arthritidis mitogen+ peptide
- 2xn9, 3qib, 1zgl, 3qiu, 3qiw, 3mbe - mMHC I + T cell receptor + peptide
- 2pxy, 1u3h - mMHC II α+β + T cell receptor (mutant) + peptide
- 1jl4 - mMHC II α+β + CD4 + peptide
- MHC II quaternary complex
- 2icw - mMHC II α+β + T cell receptor + mycoplasma arthritidis mitogen + hemagglutinin peptide
- 4c56 - hMHC II + + T cell receptor + enterotoxin + hemagglutinin peptide
ReferencesReferences
- ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
- ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
- ↑ Liu J, Chen KY, Ren EC. Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines. Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370. PMID:21538979 doi:10.1002/eji.201041370
