2lnv: Difference between revisions
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==Solution structure of GspC-HR of typeII secretion system== | ==Solution structure of GspC-HR of typeII secretion system== | ||
<StructureSection load='2lnv' size='340' side='right' caption='[[2lnv]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | <StructureSection load='2lnv' size='340' side='right' caption='[[2lnv]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
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<table><tr><td colspan='2'>[[2lnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicd3 Dicd3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNV FirstGlance]. <br> | <table><tr><td colspan='2'>[[2lnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicd3 Dicd3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LNV FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">outC, Dda3937_02414 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198628 DICD3])</td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">outC, Dda3937_02414 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198628 DICD3])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnv OCA], [http://pdbe.org/2lnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lnv RCSB], [http://www.ebi.ac.uk/pdbsum/2lnv PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnv OCA], [http://pdbe.org/2lnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lnv RCSB], [http://www.ebi.ac.uk/pdbsum/2lnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
Revision as of 22:45, 1 August 2018
Solution structure of GspC-HR of typeII secretion systemSolution structure of GspC-HR of typeII secretion system
Structural highlights
Function[GSPC2_DICD3] Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for the translocation of the multiple pectic enzymes. Publication Abstract from PubMedThe type II secretion system of Gram-negative bacteria is important for bacterial pathogenesis and survival; it is composed of 12 mostly multimeric core proteins, which build a sophisticated secretion machine spanning both bacterial membranes. OutC is the core component of the inner membrane subcomplex thought to be involved in both recognition of substrate and interaction with the outer membrane secretin OutD. Here, we report the solution structure of the HR domain of OutC and explore its interaction with the secretin. The HR domain adopts a beta-sandwich-like fold consisting of two beta-sheets each composed of three anti-parallel beta-strands. This structure is strikingly similar to the periplasmic region of PilP, an inner membrane lipoprotein from the type IV pilus system highlighting the common evolutionary origin of these two systems and showing that all the core components of the type II secretion system have a structural or sequence ortholog within the type IV pili system. The HR domain is shown to interact with the N0 domain of the secretin. The importance of this interaction is explored in the context of the functional secretion system. Solution Structure of Homology Region (HR) Domain of Type II Secretion System.,Gu S, Kelly G, Wang X, Frenkiel T, Shevchik VE, Pickersgill RW J Biol Chem. 2012 Mar 16;287(12):9072-80. Epub 2012 Jan 17. PMID:22253442[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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