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==Structure of the mouse SorCS2-NGF complex== | |||
<StructureSection load='6ffy' size='340' side='right' caption='[[6ffy]], [[Resolution|resolution]] 3.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ffy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FFY FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fg9|6fg9]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ffy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ffy OCA], [http://pdbe.org/6ffy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ffy RCSB], [http://www.ebi.ac.uk/pdbsum/6ffy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ffy ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NGF_MOUSE NGF_MOUSE]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Janssen, B J.C]] | |||
[[Category: Leloup, N O.L]] | |||
[[Category: Apoptosis]] | |||
[[Category: Neuroplasticity]] | |||
[[Category: P75ntr]] | |||
[[Category: Prongf]] | |||
[[Category: Sorcs2]] | |||
[[Category: Sortilin]] | |||
[[Category: Vps10]] | |||
Revision as of 21:54, 1 August 2018
Structure of the mouse SorCS2-NGF complexStructure of the mouse SorCS2-NGF complex
Structural highlights
Function[NGF_MOUSE] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. |
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