6dra: Difference between revisions

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-'''Unreleased structure'''
+{{Large structure}}
+==Low IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor==
+<StructureSection load='6dra' size='340' side='right' caption='[[6dra]], [[Resolution|resolution]] 3.96&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6dra]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRA FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dra OCA], [http://pdbe.org/6dra PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dra RCSB], [http://www.ebi.ac.uk/pdbsum/6dra PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dra ProSAT]</span></td></tr>
+</table>
+{{Large structure}}
+== Function ==
+[[http://www.uniprot.org/uniprot/ITPR3_HUMAN ITPR3_HUMAN]] Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Inositol trisphosphate receptors (IP3Rs) are ubiquitous Ca(2+)-permeable channels that mediate release of Ca(2+) from the endoplasmic reticulum, thereby regulating numerous processes including cell division, cell death, differentiation and fertilization. IP3Rs are jointly activated by inositol trisphosphate (IP3) and their permeant ion, Ca(2+). At high concentrations, however, Ca(2+) inhibits activity, ensuring precise spatiotemporal control over intracellular Ca(2+). Despite extensive characterization of IP3R, the mechanisms through which these molecules control channel gating have remained elusive. Here, we present structures of full-length human type 3 IP3Rs in ligand-bound and ligand-free states. Multiple IP3-bound structures demonstrate that the large cytoplasmic domain provides a platform for propagation of long-range conformational changes to the ion-conduction gate. Structures in the presence of Ca(2+) reveal two Ca(2+)-binding sites that induce the disruption of numerous interactions between subunits, thereby inhibiting IP3R. These structures thus provide a mechanistic basis for beginning to understand the regulation of IP3R.
-The entry 6dra is ON HOLD  until Paper Publication
+Structural basis for the regulation of inositol trisphosphate receptors by Ca(2+) and IP3.,Paknejad N, Hite RK Nat Struct Mol Biol. 2018 Jul 16. pii: 10.1038/s41594-018-0089-6. doi:, 10.1038/s41594-018-0089-6. PMID:30013099<ref>PMID:30013099</ref>
-Authors: Hite, R.K., Paknejad, N.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Low IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor
+<div class="pdbe-citations 6dra" style="background-color:#fffaf0;"></div>
-[[Category: Unreleased Structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hite, R K]]
 [[Category: Paknejad, N]]
-[[Category: Hite, R.K]]
+[[Category: Calcium channel]]
+[[Category: Ion channel]]
+[[Category: Metal transport]]