6cv7: Difference between revisions
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==Mouse Protocadherin-15 Extracellular Cadherin Domains 1 through 3== | |||
<StructureSection load='6cv7' size='340' side='right' caption='[[6cv7]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cv7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CV7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cv7 OCA], [http://pdbe.org/6cv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cv7 RCSB], [http://www.ebi.ac.uk/pdbsum/6cv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cv7 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PCD15_MOUSE PCD15_MOUSE]] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dionne, G]] | |||
[[Category: Shapiro, L]] | |||
[[Category: Cadherin]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Dimer]] | |||
[[Category: Hair cell]] | |||
[[Category: Hearing]] | |||
[[Category: Signaling protein]] | |||
Revision as of 21:48, 1 August 2018
Mouse Protocadherin-15 Extracellular Cadherin Domains 1 through 3Mouse Protocadherin-15 Extracellular Cadherin Domains 1 through 3
Structural highlights
Disease[PCD15_MOUSE] Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia. Function[PCD15_MOUSE] Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function. |
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