5y1w: Difference between revisions

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'''Unreleased structure'''


The entry 5y1w is ON HOLD  until Paper Publication
==Crystal structure of Plasmodium falciparum aminopeptidase N with Magnesium bound to active site Zinc==
 
<StructureSection load='5y1w' size='340' side='right' caption='[[5y1w]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
Authors: Marapaka, A.K., Addlagatta, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5y1w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y1W FirstGlance]. <br>
Description: Crystal structure of Plasmodium falciparum aminopeptidase N with Magnesium bound to active site Zinc
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y1w OCA], [http://pdbe.org/5y1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y1w RCSB], [http://www.ebi.ac.uk/pdbsum/5y1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y1w ProSAT]</span></td></tr>
[[Category: Marapaka, A.K]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ]] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Addlagatta, A]]
[[Category: Addlagatta, A]]
[[Category: Marapaka, A K]]
[[Category: Hydrolase]]
[[Category: M1-class aminopeptidase]]

Revision as of 21:38, 1 August 2018

Crystal structure of Plasmodium falciparum aminopeptidase N with Magnesium bound to active site ZincCrystal structure of Plasmodium falciparum aminopeptidase N with Magnesium bound to active site Zinc

Structural highlights

5y1w is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.[1] [2]

References

  1. ↑ Allary M, Schrevel J, Florent I. Properties, stage-dependent expression and localization of Plasmodium falciparum M1 family zinc-aminopeptidase. Parasitology. 2002 Jul;125(Pt 1):1-10. PMID:12166515
  2. ↑ McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A. 2009 Feb 5. PMID:19196988

5y1w, resolution 1.56Å

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