5y1h: Difference between revisions

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-'''Unreleased structure'''
-The entry 5y1h is ON HOLD  until Paper Publication
+==Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2,4-difluorobenzyl)ureido)-N-hydroxy-4-methylpentanamide==
+<StructureSection load='5y1h' size='340' side='right' caption='[[5y1h]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
-Authors: Marapaka, A.K., Zhang, Y., Addlagatta, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5y1h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y1H FirstGlance]. <br>
-Description: Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2,4-difluorobenzyl)ureido)-N-hydroxy-4-methylpentanamide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E8C:(2R)-2-[[2,4-bis(fluoranyl)phenyl]methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide'>E8C</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y1h OCA], [http://pdbe.org/5y1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y1h RCSB], [http://www.ebi.ac.uk/pdbsum/5y1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y1h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ]] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Addlagatta, A]]
+[[Category: Marapaka, A K]]
 [[Category: Zhang, Y]]
-[[Category: Addlagatta, A]]
+[[Category: Hydrolase]]
-[[Category: Marapaka, A.K]]
+[[Category: M1-class aminopeptidase]]