2l2g: Difference between revisions
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==Solution structure of Opossum Domain 11== | ==Solution structure of Opossum Domain 11== | ||
<StructureSection load='2l2g' size='340' side='right' caption='[[2l2g]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2l2g' size='340' side='right' caption='[[2l2g]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
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<table><tr><td colspan='2'>[[2l2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gray_short-tailed_opossum Gray short-tailed opossum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2G FirstGlance]. <br> | <table><tr><td colspan='2'>[[2l2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gray_short-tailed_opossum Gray short-tailed opossum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2G FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cnj|2cnj]], [[1gp0|1gp0]], [[2l2h|2l2h]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cnj|2cnj]], [[1gp0|1gp0]], [[2l2h|2l2h]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2g OCA], [http://pdbe.org/2l2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l2g RCSB], [http://www.ebi.ac.uk/pdbsum/2l2g PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2g OCA], [http://pdbe.org/2l2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l2g RCSB], [http://www.ebi.ac.uk/pdbsum/2l2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2l2g" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2l2g" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 10:46, 25 July 2018
Solution structure of Opossum Domain 11Solution structure of Opossum Domain 11
Structural highlights
Publication Abstract from PubMedPlacental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In monotremes, which lack imprinting, IGF2 specifically bound M6P/IGF2R via a hydrophobic CD loop. We show that the DNA coding the CD loop in monotremes functions as an exon splice enhancer (ESE) and that structural evolution of binding site loops (AB, HI, FG) improved therian IGF2 affinity. We propose that ESE evolution led to the fortuitous acquisition of IGF2 binding by M6P/IGF2R that drew IGF2R into parental conflict; subsequent imprinting may then have accelerated affinity maturation. An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.,Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, Mungall AJ, Jones EY, Crump MP, Hassan AB Science. 2012 Nov 30;338(6111):1209-13. doi: 10.1126/science.1228633. PMID:23197533[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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