6fqq

Crystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNACrystal structure of TALE homeobox domain transcription factor TGIF1 double alanine mutant bound to its consensus DNA

Structural highlights 6fqq is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: Related: 6fqp Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease [TGIF1_HUMAN] Septopreoptic holoprosencephaly;Semilobar holoprosencephaly;Lobar holoprosencephaly;Alobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly;Microform holoprosencephaly. The disease is caused by mutations affecting the gene represented in this entry. Function [TGIF1_HUMAN] Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.

spinqualitylabelsall models 6fqq, resolution 3.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image