5obb: Difference between revisions

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'''Unreleased structure'''


The entry 5obb is ON HOLD  until Paper Publication
==Structure of a modified mouse H chain ferritin with a lanthanide binding motif in complex with Terbium==
 
<StructureSection load='5obb' size='340' side='right' caption='[[5obb]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
Authors: Baiocco, P., Trabuco, M.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5obb]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OBB FirstGlance]. <br>
Description: Structure of a modified mouse H chain ferritin with a lanthanide binding motif in complex with Terbium
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5obb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5obb OCA], [http://pdbe.org/5obb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5obb RCSB], [http://www.ebi.ac.uk/pdbsum/5obb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5obb ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FRIH_MOUSE FRIH_MOUSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.<ref>PMID:19154717</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Ferroxidase]]
[[Category: Baiocco, P]]
[[Category: Baiocco, P]]
[[Category: Trabuco, M.C]]
[[Category: Trabuco, M C]]
[[Category: Ferritin]]
[[Category: Lanthanide]]
[[Category: Metal transport]]
[[Category: Terbium]]

Revision as of 10:07, 25 July 2018

Structure of a modified mouse H chain ferritin with a lanthanide binding motif in complex with TerbiumStructure of a modified mouse H chain ferritin with a lanthanide binding motif in complex with Terbium

Structural highlights

5obb is a 24 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:Ferroxidase, with EC number 1.16.3.1
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FRIH_MOUSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.[1]

References

  1. ↑ Li JY, Paragas N, Ned RM, Qiu A, Viltard M, Leete T, Drexler IR, Chen X, Sanna-Cherchi S, Mohammed F, Williams D, Lin CS, Schmidt-Ott KM, Andrews NC, Barasch J. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell. 2009 Jan;16(1):35-46. doi: 10.1016/j.devcel.2008.12.002. PMID:19154717 doi:http://dx.doi.org/10.1016/j.devcel.2008.12.002

5obb, resolution 2.65Å

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