6e07: Difference between revisions

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-'''Unreleased structure'''
-The entry 6e07 is ON HOLD
+==Crystal structure of Canton G6PD in complex with structural NADP==
+<StructureSection load='6e07' size='340' side='right' caption='[[6e07]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-Authors: Rahighi, S., Wakatsuki, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6e07]] is a 8 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5vg5 5vg5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E07 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E07 FirstGlance]. <br>
-Description: Crystal structure of Canton G6PD in complex with structural NADP
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-6-phosphate_dehydrogenase Glucose-6-phosphate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.49 1.1.1.49] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e07 OCA], [http://pdbe.org/6e07 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e07 RCSB], [http://www.ebi.ac.uk/pdbsum/6e07 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e07 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN]] Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:[http://omim.org/entry/305900 305900]]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.<ref>PMID:1611091</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/G6PD_HUMAN G6PD_HUMAN]] Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Glucose-6-phosphate dehydrogenase]]
+[[Category: Mochly-Rosen, D]]
 [[Category: Rahighi, S]]
 [[Category: Wakatsuki, S]]
+[[Category: G6pd]]
+[[Category: Nadp]]
+[[Category: Oxidoreductase]]